Title:Recent Findings on the Effects of Pharmacological Agents on the Nerve Regeneration after Peripheral Nerve Injury
Volume: 18
Issue: 11
Author(s): Samira Bolandghamat and Morteza Behnam-Rassouli*
Affiliation:
- Department of Biology, Faculty of Science, Ferdowsi University of Mashhad,Iran
Keywords:
Peripheral nerve injury, pharmacological agents, nerve regeneration, nerve repair, pharmacotherapy, functional
recovery.
Abstract: Peripheral nerve injuries (PNIs) are accompanied with neuropathic pain and functional
disability. Despite improvements in surgical repair techniques in recent years, the functional recovery
is yet unsatisfied. Indeed a successful nerve repair depends not only on the surgical strategy but
also on the cellular and molecular mechanisms involved in traumatic nerve injury. In contrast to all
strategies suggested for nerve repair, pharmacotherapy is a cheap, accessible and non-invasive
treatment that can be used immediately after nerve injury. This study aimed to review the effects of
some pharmacological agents on the nerve regeneration after traumatic PNI evaluated by functional,
histological and electrophysiological assessments. In addition, some cellular and molecular mechanisms
responsible for their therapeutic actions, restricted to neural tissue, are suggested. These findings
can not only help to find better strategies for peripheral nerve repair, but also to identify the
neuropathic effects of various medications and their mechanisms of action.
