Title:Regulation of Cl- Electrolyte Permeability in Epithelia by Active Traditional Chinese Medicine Monomers for Diarrhea
Volume: 21
Issue: 9
Author(s): Lei Chen, Yan Ding*, Yapeng Hou, Yanhong Liu and Hongguang Nie
Affiliation:
- Department of Stem Cells and Regenerative Medicine, College of Basic Medical Science, China Medical University, Shenyang,China
Keywords:
Cl- electrolyte transport, active traditional Chinese medicine monomers, ion channels, cystic fibrosis transmembrane
conductance regulator, diarrhea, epithelial tissues.
Abstract: The epithelial layer, lining the inner surface of the mammalian alveolar, kidney, brain and
colon, is a typical electrolyte transporting tissue. Large quantities of salt and fluid are actively moved
from the mucosal side toward the blood vessel. Transepithelial salt re-absorption in epithelial tissues
plays an important role in maintaining fluid homeostasis. In absorptive epithelium, fluid and salt flux
is controlled by the machinery mainly composed of epithelial sodium channel, cystic fibrosis transmembrane
conductance regulator, Na+-K+-2Cl- cotransporter, Na+/H+ exchanger, and Na+/K+-ATPase.
Dysregulation of salt permeability across epithelium contributes to the pathogenesis of organ edema.
In numerous ion transporters, epithelial Cl- transportation plays an important role in water secretion
across epithelial tissues and regulation of body fluid content. Many traditional Chinese medicines treat
diarrhea by regulating the Cl- electrolyte transport. We systematically summarized the recent progress
regarding the traditional Chinese medicine on Cl- electrolyte transport in the intestinal epithelial tissues.
The pharmaceutical relevance of developing advanced strategies to mitigate edematous disorders
is also implicated. In conclusion, the crosstalk between Cl- electrolyte transport and active traditional
Chinese medicine monomers may lead to the development of new strategies for diarrhea by manipulating
the function and expression of ion channels.
