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Review Article

IL-37作为潜在的炎症性生物疗法

卷 21, 期 9, 2020

页: [855 - 863] 页: 9

弟呕挨: 10.2174/1389450121666200429114926

价格: $65

摘要

白介素37（IL-37）被发现是促炎性IL-1超家族的新成员。 但是，进一步的研究表明，IL-37在先天性和适应性免疫中起着至关重要的抗炎作用。 IL-37可能分别通过细胞内SMAD家族成员3（SMAD3）和细胞外IL-18受体α（IL-18Rα）信号传导途径抑制炎症过程。 同时，在免疫介导的炎症性疾病中观察到IL-37的异常表达，例如炎症性肠病，类风湿性关节炎，动脉粥样硬化，系统性红斑狼疮，哮喘和多发性硬化，这表明IL-37是这些疾病潜在的治疗靶点。 在这篇综述中，我们总结了IL-37的抗炎机制，并讨论了IL-37在这些疾病的发病机理中的关键作用。 需要进一步的研究以证实IL-37作为这些炎性疾病的新靶标的有效性。

关键词: 白细胞介素37，炎性疾病，抗炎，细胞因子，免疫介导的炎性，类风湿关节炎。

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