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General Review Article

成纤维细胞生长因子作为管理神经性疼痛障碍的工具

卷 21, 期 10, 2020

页: [1034 - 1043] 页: 10

弟呕挨: 10.2174/1389450121666200423084205

价格: $65

摘要

神经性疼痛是由体感神经系统的损害或功能障碍引起的。 神经性疼痛的主要机制包括伤害性神经的异位活性，外周和中枢敏化，抑制调节受损以及小胶质细胞活化。 成纤维细胞生长因子（FGFs）是一大类生长因子，可通过RAS / MAP激酶途径，PI3激酶/ Akt途径和PLCγ这三个主要的关键信号传导途径介导神经发育，代谢和功能。 最近，FGF系统的成员与神经性疼痛的改善之间的联系变得明显。 可以预期这些信号分子为神经性疼痛的治疗提供新的药物靶标。 据我们所知，这是第一个回顾FGF系统某些成员与神经性疼痛之间关系的研究。

关键词: 成纤维细胞生长因子（FGFs），神经性疼痛，中枢敏化，炎症，体感，抑制性调节。

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图形摘要

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