Title:Bioactive Compounds in Diabetic Cardiomyopathy: Current Approaches and Potential Diagnostic and Therapeutic Targets
Volume: 19
Issue: 2
Author(s): Sandeep K. Kotturu, Veera V.S. Uddandrao, Sudip Ghosh and Brahmanaidu Parim*
Affiliation:
- Animal Physiology and Biochemistry Laboratory, ICMRNational Animal Resource Facility for Biomedical Research, Genome Valley, Hyderabad-500101, Telangana,India
Keywords:
Bioactive compounds, diabetic cardiomyopathy, endothelial dysfunction, hyperglycemia, insulin pathway, plant
products.
Abstract:
Background: Diabetic Cardiomyopathy (DCM) has an adverse effect on health and occurs
with or without concurrent vascular disease. Although several pathological mechanisms have been
implicated in DCM, oxidative stress is widely thought to be the foremost cause for DCM pathogenesis.
Objective: In this review, we focused on the role of bioactive compounds from different sources such
as plant and marine products in cardiomyopathy.
Results: Natural Products (NPs) and their constituents were traditionally considered implausible as
therapeutic agents. In the last few decades, studies on the use of NPs in the pharmaceutical field have
reduced due to problems such as the requirement of compatibility of conventional NP extract libraries
with high-throughput selection. The characteristics of NP structures such as high chemical variety,
biochemical specificity, and other molecular properties that make them favorable as direct structures
for drug synthesis and that distinguish them from combinatorial and synthetic compound libraries
have been documented since ancient times.
Conclusion: Consequently, the aim of this review was to provide an overview on the recent progress
and development of bioactive compounds in DCM and to focus on the cellular mechanisms underlying
cardiomyocyte dysfunction in their therapeutic targets.
