Title:Cancer Stemness as a Target for Immunotherapy is Shaped by Proinflammatory Stress
Volume: 16
Issue: 7
Author(s): Nese Unver*
Affiliation:
- Department of Stem Cell Sciences, Graduate School of Health Sciences, Center for Stem Cell Research and Development, Hacettepe University, Sihhiye, 06100, Ankara,Turkey
Keywords:
Inflammation, cancer stemness, pro-inflammatory stress, cancer stem cells, pro-inflammatory cytokines, immunotherapeutic
strategies.
Abstract: Cancer stem cells represent a rare subpopulation of cancer cells carrying self-renewal and
differentiation features in multi-step tumorigenesis, tumor recurrence and metastasis. Proinflammatory
stress is highly associated with cancer stemness via induction of cytokines, tumorpromoting
immune cells and cancer stemness-related signaling pathways. This review summarizes the
major pro-inflammatory factors affecting cancer stem cell characteristics and the critical immunotherapeutic
strategies to eliminate cancer stem cells.
