Title:The Roles of microRNAs in Multidrug-Resistance Mechanisms in Gastric Cancer
Volume: 20
Issue: 9
Author(s): Xi Zeng, Hao-Ying Wang, Su-Yang Bai, Ke Pu, Yu-Ping Wang and Yong-Ning Zhou*
Affiliation:
- Department of Gastroenterology, The first Hospital of Lanzhou University, Lanzhou,China
Keywords:
microRNAs, chemotherapy, multidrug resistance, gastric cancer, mechanisms, MDR.
Abstract: Multidrug resistance (MDR) is one of the most significant reasons for the
chemotherapeutics failure in gastric cancer. Although accumulating investigations and
researches have been made to elucidate the mechanisms of multidrug resistance, the
detail is far from completely understood. The importance of microRNAs in cancer
chemotherapeutic resistance has been demonstrated recently, which provides a new
strategy to overcome multidrug resistance. The different mechanisms are related to the
phenomena of MDR itself and the roles of miRNAs in these multi-mechanisms by which
MDR is acquired. In turn, the aim of this review was to summarize recent publications of
microRNAs in regulating MDR in gastric cancer, thereby potentially developing as
targeted therapies. Further unraveling the roles of microRNAs in MDR mechanisms
including the ATP-binding cassette (ABC) transporter family, autophagy induction,
cancer stem cell regulation, hypoxia induction, DNA damage and repair, epigenetic
regulation, and exosomes in gastric cancer will be helpful for us to win the battle against
it.
