Stem Cell Aging in Lifespan and Disease: A State-of-the-Art Review

Saba       Sameri; Pouria       Samadi; Razieh       Dehghan; Elham       Salem; Nashmin       Fayazi; Razieh       Amini
doi:10.2174/1574888X15666200213105155
Abstract

Aging is considered as inevitable changes at different levels of genome, cell, and organism. From the accumulation of DNA damages to imperfect protein homeostasis, altered cellular communication and exhaustion of stem cells, aging is a major risk factor for many prevalent diseases, such as cancer, cardiovascular disease, pulmonary disease, diabetes, and neurological disorders. The cells are dynamic systems, which, through a cycle of processes such as replication, growth, and death, could replenish the bodies’ organs and tissues, keeping an entire organism in optimal working order. In many different tissues, adult stem cells are behind these processes, replenishing dying cells to maintain normal tissue function and regenerating injured tissues. Therefore, adult stem cells play a vital role in preventing the aging of organs and tissues, and can delay aging. However, during aging, these cells also undergo some detrimental changes such as alterations in the microenvironment, a decline in the regenerative capacity, and loss of function. This review aimed to discuss age-related changes of stem cells in different tissues and cells, including skin, muscles, brain, heart, hair follicles, liver, and lung.
Keywords: Aging, stem cell, age-related diseases, senescence, neurodegeneration, tumor microenvironment.
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DOI https://dx.doi.org/10.2174/1574888X15666200213105155	Print ISSN 1574-888X
Publisher Name Bentham Science Publisher	Online ISSN 2212-3946
Current Stem Cell Research & Therapy

Stem Cell Aging in Lifespan and Disease: A State-of-the-Art Review

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