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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

Mitochondria-Associated Membranes (MAMs): A Novel Therapeutic Target for Treating Metabolic Syndrome

Author(s): Ming Yang, Chenrui Li and Lin Sun*

Volume 28, Issue 7, 2021

Published on: 12 February, 2020

Page: [1347 - 1362] Pages: 16

DOI: 10.2174/0929867327666200212100644

Price: $65

Abstract

Mitochondria-associated Endoplasmic Reticulum (ER) Membranes (MAMs) are the cellular structures that connect the ER and mitochondria and mediate communication between these two organelles. MAMs have been demonstrated to be involved in calcium signaling, lipid transfer, mitochondrial dynamic change, mitophagy, and the ER stress response. In addition, MAMs are critical for metabolic regulation, and their dysfunction has been reported to be associated with metabolic syndrome, including the downregulation of insulin signaling and the accelerated progression of hyperlipidemia, obesity, and hypertension. This review covers the roles of MAMs in regulating insulin sensitivity and the molecular mechanism underlying MAM-regulated cellular metabolism and reveals the potential of MAMs as a therapeutic target in treating metabolic syndrome.

Keywords: Mitochondria, endoplasmic reticulum (ER), mitochondria-associated membrane (MAM), metabolic syndrome, diabetes, insulin resistance.

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