Title:Circular RNA and Diabetes: Epigenetic Regulator with Diagnostic Role
Volume: 20
Issue: 7
关键词:
环状RNA,糖尿病,生物标志物,circRNA_0054633,circHIPK3,circANKRD36。
摘要: Circular RNAs, a group of endogenous non-coding RNAs, are characterized
by covalently closed cyclic structures with no poly-adenylated tails. It has been recently
recommended that cirRNAs have an essential role in regulating genes expression by
functioning as a translational regulator, RNA binding protein sponge and microRNA
sponge. Due to their close relation to the progression of various diseases such as
diabetes, circRNAs have become a research hotspot. A number of circRNAs (i.e.,
circRNA_0054633, circHIPK3, circANKRD36, and circRNA11783-2) have been shown
to be associated with initiation and progression of diabetes. Based on reports, in a
tissue, some circRNAs are expressed in a developmental stage-specific manner. In this
study, we reviewed research on circular RNAs involved in the pathogenesis and
diagnosis of diabetes and their prognostic roles.