Title:Antibacterial Agents Targeting the Bacterial Cell Wall
Volume: 27
Issue: 17
关键词:
抗生素,细菌细胞壁,肽聚糖,酵素,综述,细菌感染。
摘要: The introduction of antibiotics to treat bacterial infections either by killing or blocking their
growth has been accompanied by the studies of mechanism that allows the drugs to kill the bacteria or
to stop their proliferation. In such a scenario, the emergence of antibacterial agents active on the bacterial
cell wall has been of fundamental importance in the fight against bacterial agents responsible for
severe diseases. As a matter of fact, the cell wall, which plays many roles during the lifecycle, is an
essential constituent of most bacteria. This overview focuses on the intracellular steps of peptidoglycan
biosynthesis and the research of new antibacterial agents based on the enzymes involved in these early
steps of the formation of cell membrane components.