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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Review Article

Exploring Dysregulated Signaling Pathways in Cancer

Author(s): Sabah Nisar , Sheema Hashem, Muzafar A. Macha , Santosh K. Yadav, Sankavi Muralitharan , Lubna Therachiyil, Geetanjali Sageena, Hamda Al-Naemi, Mohammad Haris and Ajaz A. Bhat*

Volume 26, Issue 4, 2020

Page: [429 - 445] Pages: 17

DOI: 10.2174/1381612826666200115095937

Price: $65

Abstract

Cancer cell biology takes advantage of identifying diverse cellular signaling pathways that are disrupted in cancer. Signaling pathways are an important means of communication from the exterior of cell to intracellular mediators, as well as intracellular interactions that govern diverse cellular processes. Oncogenic mutations or abnormal expression of signaling components disrupt the regulatory networks that govern cell function, thus enabling tumor cells to undergo dysregulated mitogenesis, to resist apoptosis, and to promote invasion to neighboring tissues. Unraveling of dysregulated signaling pathways may advance the understanding of tumor pathophysiology and lead to the improvement of targeted tumor therapy. In this review article, different signaling pathways and how their dysregulation contributes to the development of tumors have been discussed.

Keywords: Angiogenesis, apoptosis, cell invasion, cell proliferation, drug targets, metastasis, signaling pathways, tumor microenvironment.

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