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Review Article

白藜芦醇在调节人类疾病中的microRNA中的作用:从癌症到炎症障碍

卷 28, 期 2, 2021

发表于: 12 December, 2019

页: [360 - 376] 页: 17

弟呕挨: 10.2174/0929867326666191212102407

价格: $65

摘要

癌症和炎症性疾病是世界范围内两个重要的公共卫生问题，具有重大的社会经济影响。尽管有一些努力，目前的治疗平台有严重的局限性。因此，开发新的治疗策略来治疗这些疾病是当务之急。除了目前的治疗方法外，天然化合物的利用也为癌症和炎症疾病的治疗开辟了新的视野。这些天然化合物既可以单独使用，也可以与标准的癌症治疗方式(如化疗、放疗和免疫治疗)联合使用。白藜芦醇是一种多酚化合物，存在于葡萄和其他食物中。研究发现，该药物具有广泛的药理作用，包括抗癌、抗炎、抗微生物和抗氧化活性。近年来，白藜芦醇的抗肿瘤和抗炎作用已成为临床和临床前研究的热点。越来越多的证据表明，白藜芦醇通过靶向多种细胞和分子机制发挥其治疗作用。在白藜芦醇调控的细胞和分子靶标中，microRNA (miRNAs)已成为关键靶标。miRNA是短的非编码RNA，起表观遗传调节作用。这些分子参与了癌症和炎症疾病的起始和进展的许多过程。在此，我们总结了在癌症和炎症疾病中直接/间接受白藜芦醇影响的各种miRNA。

关键词: 白藜芦醇，microRNA，癌症，治疗，非编码RNA，非癌症疾病。

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