Title:Resveratrol: A New Potential Therapeutic Agent for Melanoma?
Volume: 28
Issue: 4
关键词:
黑色素瘤，白藜芦醇，治疗，天然化合物，细胞凋亡，血管生成
摘要:
Melanoma is the most life-threatening and aggressive class of skin malignancies. The incidence
of melanoma has steadily increased. Metastatic melanoma is greatly resistant to standard antimelanoma
treatments such as chemotherapy, and the 5-year survival rate of cases with melanoma
who have a metastatic form of the disease is less than 10%. The contributing role of apoptosis, angiogenesis
and autophagy in the pathophysiology of melanoma has been previously demonstrated. Thus,
it is extremely urgent to search for complementary therapeutic approaches that could enhance the
quality of life of subjects and reduce treatment resistance and adverse effects. Resveratrol, known as a
polyphenol component present in grapes and some plants, has anti-cancer properties due to its function
as an apoptosis inducer in tumor cells, and anti-angiogenic agent to prevent metastasis. However,
more clinical trials should be conducted to prove resveratrol efficacy.
Herein, for the first time, we summarize the current knowledge of anti-cancerous activities of resveratrol
in melanoma.
