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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Review Article

Synthetic Methods Applied in the Preparation of Coumarin-based Compounds

Author(s): Carla S. Francisco, Cristina S. Francisco, André F. Constantino, Álvaro Cunha Neto and Valdemar Lacerda Jr.*

Volume 23, Issue 24, 2019

Page: [2722 - 2750] Pages: 29

DOI: 10.2174/1385272823666191121150047

Price: $65

Abstract

Coumarins (2H-chromen-2-ones) are heterocyclic compounds of wide scientific interest due to their important biological and pharmaceutical properties such as antitumor, antioxidant, anti-inflammatory and antimicrobial activities as well as enzymatic inhibitors related to neurodegenerative diseases. Due to their structural variability, this compound class has been attracting considerable interest in the natural products and synthetic organic chemistry areas. Coumarins and their derivatives have been prepared by a variety of methods, including Perkin, Wittig and Reformatsky reactions, Pechmann and Knoevenagel condensations, and Claisen rearrangement, among others. In the present review we report the different synthetic methods used in the preparation of coumarin derivatives exploited in the last ten years (from 2008 to 2018), regarding the research demand for new structural scaffolds.

Keywords: Review, coumarin, 2H-chromen-2-ones, coumarin derivatives, synthetic methods, condensation reaction.

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