Title:A Paradigm Shift in the Development of Anti-Candida Drugs
Volume: 19
Issue: 28
Author(s): D.V. Gowda*, M. Afrasim, S.I. Meenakshi, M. Manohar, S. Hemalatha, H. Siddaramaiah, P. Sathishbabu, S.M. Danish Rizvi, T. Hussain and M.A. Kamal
Affiliation:
- Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru- 570015,India
Keywords:
Candidiasis, Antifungal agents, Natural plant extracts, Novel drug therapy, Vaccination, VVC.
Abstract:
Background: The considerable increase in the incidence of Candida infection in recent times
has prompted the use of numerous antifungal agents, which has resulted in the development of resistance
towards various antifungal agents. With rising Candida infections, the need for design and development
of novel antifungal agents is in great demand. However, new therapeutic approaches are very essential
in preventing the mortality rate and improving the patient outcome in those suffering from Candida
infections.
Objective: The present review objective is to describe the burden, types of Candidiasis, mechanism of
action of antifungal agents and its resistance and the current novel approaches used to combat
candidiasis.
Methods: We have collected and analyzed 135 different peer-reviewed literature studies pertinent to
candidiasis. In this review, we have compiled the major findings from these studies.
Results and Conclusion: The review describes the concerns related to candidiasis, its current treatment
strategy, resistance mechanisms and imminent ways to tackle the problem. The review explored that
natural plant extracts and essential oils could act as sources of newer therapeutic agents, however, the
focus was on novel strategies, such as combinational therapy, new antibodies, utilization of
photodynamic therapy and adaptive transfer primed immune cells with emphasis on the development of
effective vaccination.
