Login Register Cart 0
Generic placeholder image

Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

Aquaporins and Roles in Brain Health and Brain Injury

Author(s): Dervis Dasdelen, Rasim Mogulkoc* and Abdülkerim Kasim Baltaci

Volume 20, Issue 6, 2020

Page: [498 - 512] Pages: 15

DOI: 10.2174/1389557519666191018142007

Price: $65

Abstract

In the literature screening, aquaporins were found in the cerebral structures including the pia mater, choroid plexus, ependyma, piriform cortex, hippocampus, dorsal thalamus, supraoptic and suprachiasmatic nuclei, white matter and subcortical organ. Among these, the most common are AQP1, AQP4, and AQP9. The roles of aquaporins have been demonstrated in several diseases such as cerebral edema, various central nervous system tumors, Alzheimer’s Disease and epilepsy. In this review, the relationship between brain/brain-injury and aquaporin, has been reviewed.

Keywords: Aquaporins, brain injury, diseases, epilepsy, central nervous system tumors, Alzheimer's Disease.

« Previous Next »
Graphical Abstract

[1]
Agre, P.; Saboori, A.M.; Asimos, A.; Smith, B.L. Purification and partial characterization of the Mr 30,000 integral membrane protein associated with the erythrocyte Rh(D) antigen. J. Biol. Chem., 1987, 262(36), 17497-17503.
[PMID: 3121599]
[2]
Preston, G.M.; Agre, P. Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family. Proc. Natl. Acad. Sci. USA, 1991, 88(24), 11110-11114.
[http://dx.doi.org/10.1073/pnas.88.24.11110] [PMID: 1722319]
[3]
Preston, G.M.; Carroll, T.P.; Guggino, W.B.; Agre, P. Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein. Science, 1992, 256(5055), 385-387.
[http://dx.doi.org/10.1126/science.256.5055.385] [PMID: 1373524]
[4]
Agre, P.; Sasaki, S.; Chrispeels, M.J. Aquaporins: a family of water channel proteins. Am. J. Physiol., 1993, 265(3 Pt 2), F461.
[PMID: 7692747]
[5]
Gonen, T.; Walz, T. The structure of aquaporins. Q. Rev. Biophys., 2006, 39(4), 361-396.
[http://dx.doi.org/10.1017/S0033583506004458] [PMID: 17156589]
[6]
Michalek, K. Aquaglyceroporins in the kidney: present state of knowledge and prospects. J. Physiol. Pharmacol., 2016, 67(2), 185-193.
[PMID: 27226178]
[7]
Yamamoto, N.; Yoneda, K.; Asai, K.; Sobue, K.; Tada, T.; Fujita, Y.; Katsuya, H.; Fujita, M.; Aihara, N.; Mase, M.; Yamada, K.; Miura, Y.; Kato, T. Alterations in the expression of the AQP family in cultured rat astrocytes during hypoxia and reoxygenation. Brain Res. Mol. Brain Res., 2001, 90(1), 26-38.
[http://dx.doi.org/10.1016/S0169-328X(01)00064-X] [PMID: 11376853]
[8]
Zardoya, R. Phylogeny and evolution of the major intrinsic protein family. Biol. Cell, 2005, 97(6), 397-414.
[http://dx.doi.org/10.1042/BC20040134] [PMID: 15850454]
[9]
Morishita, Y.; Sakube, Y.; Sasaki, S.; Ishibashi, K. Molecular mechanisms and drug development in aquaporin water channel diseases: aquaporin superfamily (superaquaporins): expansion of aquaporins restricted to multicellular organisms. J. Pharmacol. Sci., 2004, 96(3), 276-279.
[http://dx.doi.org/10.1254/jphs.FMJ04004X7] [PMID: 15548852]
[10]
Itoh, T.; Rai, T.; Kuwahara, M.; Ko, S.B.; Uchida, S.; Sasaki, S.; Ishibashi, K. Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells. Biochem. Biophys. Res. Commun., 2005, 330(3), 832-838.
[http://dx.doi.org/10.1016/j.bbrc.2005.03.046] [PMID: 15809071]
[11]
Ishibashi, K. Aquaporin subfamily with unusual NPA boxes. Biochim. Biophys. Acta, 2006, 1758(8), 989-993.
[http://dx.doi.org/10.1016/j.bbamem.2006.02.024] [PMID: 16579962]
[12]
Nielsen, S.; Smith, B.L.; Christensen, E.I.; Agre, P. Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia. Proc. Natl. Acad. Sci. USA, 1993, 90(15), 7275-7279.
[http://dx.doi.org/10.1073/pnas.90.15.7275] [PMID: 8346245]
[13]
Yang, M.; Gao, F.; Liu, H.; Yu, W.H.; He, G.Q.; Zhuo, F.; Qiu, G.P.; Sun, S.Q. Immunolocalization of aquaporins in rat brain. Anat. Histol. Embryol., 2011, 40(4), 299-306.
[http://dx.doi.org/10.1111/j.1439-0264.2011.01070.x] [PMID: 21496068]
[14]
Shields, S.D.; Mazario, J.; Skinner, K.; Basbaum, A.I. Anatomical and functional analysis of aquaporin 1, a water channel in primary afferent neurons. Pain, 2007, 131(1-2), 8-20.
[http://dx.doi.org/10.1016/j.pain.2006.11.018] [PMID: 17257750]
[15]
Kobayashi, H.; Minami, S.; Itoh, S.; Shiraishi, S.; Yokoo, H.; Yanagita, T.; Uezono, Y.; Mohri, M.; Wada, A. Aquaporin subtypes in rat cerebral microvessels. Neurosci. Lett., 2001, 297(3), 163-166.
[http://dx.doi.org/10.1016/S0304-3940(00)01705-5] [PMID: 11137753]
[16]
Dolman, D.; Drndarski, S.; Abbott, N.J.; Rattray, M. Induction of aquaporin 1 but not aquaporin 4 messenger RNA in rat primary brain microvessel endothelial cells in culture. J. Neurochem., 2005, 93(4), 825-833.
[http://dx.doi.org/10.1111/j.1471-4159.2005.03111.x] [PMID: 15857386]
[17]
Kobayashi, H.; Yokoo, H.; Yanagita, T.; Satoh, S.; Kis, B.; Deli, M.; Niwa, M.; Wada, A. Induction of aquaporin 1 by dexamethasone in lipid rafts in immortalized brain microvascular endothelial cells. Brain Res., 2006, 1123(1), 12-19.
[http://dx.doi.org/10.1016/j.brainres.2006.09.066] [PMID: 17074307]
[18]
Oshio, K.; Watanabe, H.; Song, Y.; Verkman, A.S.; Manley, G.T. Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1. FASEB J., 2005, 19(1), 76-78.
[http://dx.doi.org/10.1096/fj.04-1711fje] [PMID: 15533949]
[19]
Stiebel-Kalish, H.; Eyal, S.; Steiner, I. The role of aquaporin-1 in idiopathic and drug-induced intracranial hypertension. Med. Hypotheses, 2013, 81(6), 1059-1062.
[http://dx.doi.org/10.1016/j.mehy.2013.10.002] [PMID: 24169407]
[20]
Jeon, T.; Park, K.S.; Park, S.H.; Hwang, J.H.; Hwang, S.K. Expression of Aquaporin 1 and 4 in the Choroid Plexus and Brain Parenchyma of Kaolin-Induced Hydrocephalic Rats. Korean J. Neurotrauma, 2017, 13(2), 68-75.
[http://dx.doi.org/10.13004/kjnt.2017.13.2.68] [PMID: 29201837]
[21]
Nakhoul, N.L.; Hering-Smith, K.S.; Abdulnour-Nakhoul, S.M.; Hamm, L.L. Transport of NH(3)/NH in oocytes expressing aquaporin-1. Am. J. Physiol. Renal Physiol., 2001, 281(2), F255-F263.
[http://dx.doi.org/10.1152/ajprenal.2001.281.2.F255] [PMID: 11457716]
[22]
Cooper, G.J.; Boron, W.F. Effect of PCMBS on CO2 permeability of Xenopus oocytes expressing aquaporin 1 or its C189S mutant. Am. J. Physiol., 1998, 275(6), C1481-C1486.
[http://dx.doi.org/10.1152/ajpcell.1998.275.6.C1481] [PMID: 9843709]
[23]
Echevarría, M.; Muñoz-Cabello, A.M.; Sánchez-Silva, R.; Toledo-Aral, J.J.; López-Barneo, J. Development of cytosolic hypoxia and hypoxia-inducible factor stabilization are facilitated by aquaporin-1 expression. J. Biol. Chem., 2007, 282(41), 30207-30215.
[http://dx.doi.org/10.1074/jbc.M702639200] [PMID: 17673462]
[24]
Herrera, M.; Hong, N.J.; Garvin, J.L. Aquaporin-1 transports NO across cell membranes. Hypertension, 2006, 48(1), 157-164.
[http://dx.doi.org/10.1161/01.HYP.0000223652.29338.77] [PMID: 16682607]
[25]
Kim, J.H.; Lee, Y.W.; Park, K.A.; Lee, W.T.; Lee, J.E. Agmatine attenuates brain edema through reducing the expression of aquaporin-1 after cerebral ischemia. J. Cereb. Blood Flow Metab., 2010, 30(5), 943-949.
[http://dx.doi.org/10.1038/jcbfm.2009.260] [PMID: 20029450]
[26]
Darabi, S.; Mohammadi, M.T. Fullerenol nanoparticles decrease ischaemia-induced brain injury and oedema through inhibition of oxidative damage and aquaporin-1 expression in ischaemic stroke. Brain Inj., 2017, 31(8), 1142-1150.
[http://dx.doi.org/10.1080/02699052.2017.1300835] [PMID: 28506130]
[27]
Mohammadi, M.T.; Dehghani, G.A. Nitric oxide as a regulatory factor for aquaporin-1 and 4 gene expression following brain ischemia/reperfusion injury in rat. Pathol. Res. Pract., 2015, 211(1), 43-49.
[http://dx.doi.org/10.1016/j.prp.2014.07.014] [PMID: 25441658]
[28]
Akdemir, G.; Kaymaz, F.; Gursoy-Özdemir, Y.; Akalan, N.; Akdemir, E.S. The time course changes in expression of aquaporin 4 and aquaporin 1 following global cerebral ischemic edema in rat. Surg. Neurol. Int., 2016, 7, 4.
[http://dx.doi.org/10.4103/2152-7806.173316] [PMID: 26862443]
[29]
Zhang, W.; Zitron, E.; Hömme, M.; Kihm, L.; Morath, C.; Scherer, D.; Hegge, S.; Thomas, D.; Schmitt, C.P.; Zeier, M.; Katus, H.; Karle, C.; Schwenger, V. Aquaporin-1 channel function is positively regulated by protein kinase C. J. Biol. Chem., 2007, 282(29), 20933-20940.
[http://dx.doi.org/10.1074/jbc.M703858200] [PMID: 17522053]
[30]
Anthony, T.L.; Brooks, H.L.; Boassa, D.; Leonov, S.; Yanochko, G.M.; Regan, J.W.; Yool, A.J. Cloned human aquaporin-1 is a cyclic GMP-gated ion channel. Mol. Pharmacol., 2000, 57(3), 576-588.
[http://dx.doi.org/10.1124/mol.57.3.576] [PMID: 10692499]
[31]
Hoshi, A.; Tsunoda, A.; Tada, M.; Nishizawa, M.; Ugawa, Y.; Kakita, A. Expression of Aquaporin 1 and Aquaporin 4 in the Temporal Neocortex of Patients with Parkinson’s Disease. Brain Pathol., 2017, 27(2), 160-168.
[http://dx.doi.org/10.1111/bpa.12369] [PMID: 26919570]
[32]
Noell, S.; Fallier-Becker, P.; Mack, A.F.; Hoffmeister, M.; Beschorner, R.; Ritz, R. Water channels aquaporin 4 and -1 Expression in subependymoma depends on the localization of the tumors. PLoS One, 2015, 10(6), e0131367
[http://dx.doi.org/10.1371/journal.pone.0131367] [PMID: 26115524]
[33]
Deb, P.; Pal, S.; Dutta, V.; Boruah, D.; Chandran, V.M.; Bhatoe, H.S. Correlation of expression pattern of aquaporin-1 in primary central nervous system tumors with tumor type, grade, proliferation, microvessel density, contrast-enhancement and perilesional edema. J. Cancer Res. Ther., 2012, 8(4), 571-577.
[http://dx.doi.org/10.4103/0973-1482.106542] [PMID: 23361277]
[34]
Kourghi, M.; Pei, J.V.; De Ieso, M.L.; Flynn, G.; Yool, A.J. Bumetanide derivatives AqB007 and AqB011 selectively block the aquaporin-1 Ion channel conductance and slow cancer cell migration. Mol. Pharmacol., 2016, 89(1), 133-140.
[http://dx.doi.org/10.1124/mol.115.101618] [PMID: 26467039]
[35]
Pérez, E.; Barrachina, M.; Rodríguez, A.; Torrejón-Escribano, B.; Boada, M.; Hernández, I.; Sánchez, M.; Ferrer, I. Aquaporin expression in the cerebral cortex is increased at early stages of Alzheimer disease. Brain Res., 2007, 1128(1), 164-174.
[http://dx.doi.org/10.1016/j.brainres.2006.09.109] [PMID: 17123487]
[36]
Misawa, T.; Arima, K.; Mizusawa, H.; Satoh, J. Close association of water channel AQP1 with amyloid-beta deposition in Alzheimer disease brains. Acta Neuropathol., 2008, 116(3), 247-260.
[http://dx.doi.org/10.1007/s00401-008-0387-x] [PMID: 18509662]
[37]
Hoshi, A.; Yamamoto, T.; Shimizu, K.; Ugawa, Y.; Nishizawa, M.; Takahashi, H.; Kakita, A. Characteristics of aquaporin expression surrounding senile plaques and cerebral amyloid angiopathy in Alzheimer disease. J. Neuropathol. Exp. Neurol., 2012, 71(8), 750-759.
[http://dx.doi.org/10.1097/NEN.0b013e3182632566] [PMID: 22805778]
[38]
Cacciatore, I.; Cornacchia, C.; Baldassarre, L.; Fornasari, E.; Mollica, A.; Stefanucci, A.; Pinnen, F. GPE and GPE analogues as promising neuroprotective agents. Mini Rev. Med. Chem., 2012, 12(1), 13-23.
[http://dx.doi.org/10.2174/138955712798868995] [PMID: 22070686]
[39]
Cacciatore, I.; Baldassarre, L.; Fornasari, E.; Mollica, A.; Pinnen, F. Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems. Oxid. Med. Cell. Longev., 2012, 2012 240146
[http://dx.doi.org/10.1155/2012/240146] [PMID: 22701755]
[40]
Agre, P.; King, L.S.; Yasui, M.; Guggino, W.B.; Ottersen, O.P.; Fujiyoshi, Y.; Engel, A.; Nielsen, S. Aquaporin water channels--from atomic structure to clinical medicine. J. Physiol., 2002, 542(Pt 1), 3-16.
[http://dx.doi.org/10.1113/jphysiol.2002.020818] [PMID: 12096044]
[41]
Nagelhus, E.A.; Veruki, M.L.; Torp, R.; Haug, F.M.; Laake, J.H.; Nielsen, S.; Agre, P.; Ottersen, O.P. Aquaporin-4 water channel protein in the rat retina and optic nerve: polarized expression in Müller cells and fibrous astrocytes. J. Neurosci., 1998, 18(7), 2506-2519.
[http://dx.doi.org/10.1523/JNEUROSCI.18-07-02506.1998] [PMID: 9502811]
[42]
Hsu, M.S.; Seldin, M.; Lee, D.J.; Seifert, G.; Steinhäuser, C.; Binder, D.K. Laminar-specific and developmental expression of aquaporin-4 in the mouse hippocampus. Neuroscience, 2011, 178, 21-32.
[http://dx.doi.org/10.1016/j.neuroscience.2011.01.020] [PMID: 21256195]
[43]
Wen, H.; Nagelhus, E.A.; Amiry-Moghaddam, M.; Agre, P.; Ottersen, O.P.; Nielsen, S. Ontogeny of water transport in rat brain: postnatal expression of the aquaporin-4 water channel. Eur. J. Neurosci., 1999, 11(3), 935-945.
[http://dx.doi.org/10.1046/j.1460-9568.1999.00502.x] [PMID: 10103087]
[44]
Nielsen, S.; Nagelhus, E.A.; Amiry-Moghaddam, M.; Bourque, C.; Agre, P.; Ottersen, O.P. Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain. J. Neurosci., 1997, 17(1), 171-180.
[http://dx.doi.org/10.1523/JNEUROSCI.17-01-00171.1997] [PMID: 8987746]
[45]
Badaut, J.; Nehlig, A.; Verbavatz, J.; Stoeckel, M.; Freund-Mercier, M.J.; Lasbennes, F. Hypervascularization in the magnocellular nuclei of the rat hypothalamus: relationship with the distribution of aquaporin-4 and markers of energy metabolism. J. Neuroendocrinol., 2000, 12(10), 960-969.
[http://dx.doi.org/10.1046/j.1365-2826.2000.00539.x] [PMID: 11012836]
[46]
Oshio, K.; Binder, D.K.; Yang, B.; Schecter, S.; Verkman, A.S.; Manley, G.T. Expression of aquaporin water channels in mouse spinal cord. Neuroscience, 2004, 127(3), 685-693.
[http://dx.doi.org/10.1016/j.neuroscience.2004.03.016] [PMID: 15283967]
[47]
Kuwahara, S.; Maeda, S.; Tanaka, K.; Hayakawa, T.; Seki, M. Expression of aquaporin water channels in the rat pituitary gland. J. Vet. Med. Sci., 2007, 69(11), 1175-1178.
[http://dx.doi.org/10.1292/jvms.69.1175] [PMID: 18057834]
[48]
Cavazzin, C.; Ferrari, D.; Facchetti, F.; Russignan, A.; Vescovi, A.L.; La Porta, C.A.; Gritti, A. Unique expression and localization of aquaporin-4 and aquaporin-9 in murine and human neural stem cells and in their glial progeny. Glia, 2006, 53(2), 167-181.
[http://dx.doi.org/10.1002/glia.20256] [PMID: 16206164]
[49]
Moe, S.E.; Sorbo, J.G.; Sogaard, R.; Zeuthen, T.; Petter Ottersen, O.; Holen, T. New isoforms of rat Aquaporin-4. Genomics, 2008, 91(4), 367-377.
[http://dx.doi.org/10.1016/j.ygeno.2007.12.003] [PMID: 18255256]
[50]
Neely, J.D.; Christensen, B.M.; Nielsen, S.; Agre, P. Heterotetrameric composition of aquaporin-4 water channels. Biochemistry, 1999, 38(34), 11156-11163.
[http://dx.doi.org/10.1021/bi990941s] [PMID: 10460172]
[51]
Hirt, L.; Ternon, B.; Price, M.; Mastour, N.; Brunet, J.F.; Badaut, J. Protective role of early aquaporin 4 induction against postischemic edema formation. J. Cereb. Blood Flow Metab., 2009, 29(2), 423-433.
[http://dx.doi.org/10.1038/jcbfm.2008.133] [PMID: 18985050]
[52]
Noell, S.; Fallier-Becker, P.; Beyer, C.; Kröger, S.; Mack, A.F.; Wolburg, H. Effects of agrin on the expression and distribution of the water channel protein aquaporin-4 and volume regulation in cultured astrocytes. Eur. J. Neurosci., 2007, 26(8), 2109-2118.
[http://dx.doi.org/10.1111/j.1460-9568.2007.05850.x] [PMID: 17927773]
[53]
Wang, Y.; Tajkhorshid, E. Nitric oxide conduction by the brain aquaporin AQP4. Proteins, 2010, 78(3), 661-670.
[PMID: 19842162]
[54]
Binder, D.K.; Nagelhus, E.A.; Ottersen, O.P. Aquaporin-4 and epilepsy. Glia, 2012, 60(8), 1203-1214.
[http://dx.doi.org/10.1002/glia.22317] [PMID: 22378467]
[55]
Promeneur, D.; Lunde, L.K.; Amiry-Moghaddam, M.; Agre, P. Protective role of brain water channel AQP4 in murine cerebral malaria. Proc. Natl. Acad. Sci. USA, 2013, 110(3), 1035-1040.
[http://dx.doi.org/10.1073/pnas.1220566110] [PMID: 23277579]
[56]
Chai, R.C.; Jiang, J.H.; Wong, A.Y.; Jiang, F.; Gao, K.; Vatcher, G.; Hoi Yu, A.C. AQP5 is differentially regulated in astrocytes during metabolic and traumatic injuries. Glia, 2013, 61(10), 1748-1765.
[http://dx.doi.org/10.1002/glia.22555] [PMID: 23922257]
[57]
Benfenati, V.; Caprini, M.; Dovizio, M.; Mylonakou, M.N.; Ferroni, S.; Ottersen, O.P.; Amiry-Moghaddam, M. An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes. Proc. Natl. Acad. Sci. USA, 2011, 108(6), 2563-2568.
[http://dx.doi.org/10.1073/pnas.1012867108] [PMID: 21262839]
[58]
Thrane, A.S.; Rappold, P.M.; Fujita, T.; Torres, A.; Bekar, L.K.; Takano, T.; Peng, W.; Wang, F.; Rangroo Thrane, V.; Enger, R.; Haj-Yasein, N.N.; Skare, Ø.; Holen, T.; Klungland, A.; Ottersen, O.P.; Nedergaard, M.; Nagelhus, E.A. Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proc. Natl. Acad. Sci. USA, 2011, 108(2), 846-851.
[http://dx.doi.org/10.1073/pnas.1015217108] [PMID: 21187412]
[59]
Thrane, A.S.; Takano, T.; Rangroo Thrane, V.; Wang, F.; Peng, W.; Ottersen, O.P.; Nedergaard, M.; Nagelhus, E.A. In vivo NADH fluorescence imaging indicates effect of aquaporin-4 deletion on oxygen microdistribution in cortical spreading depression. J. Cereb. Blood Flow Metab., 2013, 33(7), 996-999.
[http://dx.doi.org/10.1038/jcbfm.2013.63] [PMID: 23611872]
[60]
Schmidt, M.J.; Rummel, C.; Hauer, J.; Kolecka, M.; Ondreka, N.; McClure, V.; Roth, J. Increased CSF aquaporin-4, and interleukin-6 levels in dogs with idiopathic communicating internal hydrocephalus and a decrease after ventriculo-peritoneal shunting. Fluids Barriers CNS, 2016, 13(1), 12.
[http://dx.doi.org/10.1186/s12987-016-0034-1] [PMID: 27357498]
[61]
Yang, B.; Zador, Z.; Verkman, A.S. Glial cell aquaporin-4 overexpression in transgenic mice accelerates cytotoxic brain swelling. J. Biol. Chem., 2008, 283(22), 15280-15286.
[http://dx.doi.org/10.1074/jbc.M801425200] [PMID: 18375385]
[62]
Zador, Z.; Stiver, S.; Wang, V.; Manley, G.T. Role of aquaporin-4 in cerebral edema and stroke. Handb. Exp. Pharmacol., 2009, (190), 159-170.
[http://dx.doi.org/10.1007/978-3-540-79885-9_7] [PMID: 19096776]
[63]
Yang, M.; Gao, F.; Liu, H.; Yu, W.H.; Sun, S.Q. Temporal changes in expression of aquaporin-3, -4, -5 and -8 in rat brains after permanent focal cerebral ischemia. Brain Res., 2009, 1290, 121-132.
[http://dx.doi.org/10.1016/j.brainres.2009.07.018] [PMID: 19616516]
[64]
Deng, J.; Zhao, F.; Yu, X.; Zhao, Y.; Li, D.; Shi, H.; Sun, Y. Expression of aquaporin 4 and breakdown of the blood-brain barrier after hypoglycemia-induced brain edema in rats. PLoS One, 2014, 9(9), e107022
[http://dx.doi.org/10.1371/journal.pone.0107022] [PMID: 25264602]
[65]
Bhattacharya, P.; Pandey, A.K.; Paul, S.; Patnaik, R. Melatonin renders neuroprotection by protein kinase C mediated aquaporin-4 inhibition in animal model of focal cerebral ischemia. Life Sci., 2014, 100(2), 97-109.
[http://dx.doi.org/10.1016/j.lfs.2014.01.085] [PMID: 24530291]
[66]
Nakano, T.; Nishigami, C.; Irie, K.; Shigemori, Y.; Sano, K.; Yamashita, Y.; Myose, T.; Tominaga, K.; Matsuo, K.; Nakamura, Y.; Ishikura, H.; Kamimura, H.; Egawa, T.; Mishima, K. Goreisan prevents brain edema after cerebral ischemic stroke by inhibiting aquaporin 4 upregulation in mice. J. Stroke Cerebrovasc. Dis., 2017.
[PMID: 29153303]
[67]
Pirici, I.; Balsanu, T.A.; Bogdan, C.; Margaritescu, C.; Divan, T.; Vitalie, V.; Mogoanta, L.; Pirici, D.; Carare, R.O.; Muresanu, D.F. Inhibition of Aquaporin-4 improves the outcome of ischaemic stroke and modulates brain paravascular drainage pathways. Int. J. Mol. Sci., 2017, 19(1), 19.
[http://dx.doi.org/10.3390/ijms19010046] [PMID: 29295526]
[68]
Wang, X.; An, F.; Wang, S.; An, Z.; Wang, S. Orientin attenuates cerebral ischemia/Reperfusion injury in rat model through the AQP-4 and TLR4/NF-κB/TNF-α signaling pathway. J. Stroke Cerebrovasc. Dis., 2017, 26(10), 2199-2214.
[http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2017.05.002] [PMID: 28645524]
[69]
Yin, J.; Zhang, H.; Chen, H.; Lv, Q.; Jin, X. Hypertonic saline alleviates brain edema after traumatic brain injury via Downregulation of aquaporin 4 in rats. Med. Sci. Monit., 2018, 24, 1863-1870.
[http://dx.doi.org/10.12659/MSM.907212] [PMID: 29600800]
[70]
Amiry-Moghaddam, M.; Williamson, A.; Palomba, M.; Eid, T.; de Lanerolle, N.C.; Nagelhus, E.A.; Adams, M.E.; Froehner, S.C.; Agre, P.; Ottersen, O.P. Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice. Proc. Natl. Acad. Sci. USA, 2003, 100(23), 13615-13620.
[http://dx.doi.org/10.1073/pnas.2336064100] [PMID: 14597704]
[71]
Binder, D.K.; Yao, X.; Zador, Z.; Sick, T.J.; Verkman, A.S.; Manley, G.T. Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels. Glia, 2006, 53(6), 631-636.
[http://dx.doi.org/10.1002/glia.20318] [PMID: 16470808]
[72]
Lee, T.S.; Eid, T.; Mane, S.; Kim, J.H.; Spencer, D.D.; Ottersen, O.P.; de Lanerolle, N.C. Aquaporin-4 is increased in the sclerotic hippocampus in human temporal lobe epilepsy. Acta Neuropathol., 2004, 108(6), 493-502.
[http://dx.doi.org/10.1007/s00401-004-0910-7] [PMID: 15517312]
[73]
Huber, V.J.; Tsujita, M.; Kwee, I.L.; Nakada, T. Inhibition of aquaporin 4 by antiepileptic drugs. Bioorg. Med. Chem., 2009, 17(1), 418-424.
[http://dx.doi.org/10.1016/j.bmc.2007.12.038] [PMID: 18178093]
[74]
Salman, M.M.; Sheilabi, M.A.; Bhattacharyya, D.; Kitchen, P.; Conner, A.C.; Bill, R.M.; Woodroofe, M.N.; Conner, M.T.; Princivalle, A.P. Transcriptome analysis suggests a role for the differential expression of cerebral aquaporins and the MAPK signalling pathway in human temporal lobe epilepsy. Eur. J. Neurosci., 2017, 46(5), 2121-2132.
[http://dx.doi.org/10.1111/ejn.13652] [PMID: 28715131]
[75]
Han, X.; Huang, Q.; Liu, L.; Sha, X.; Hu, B.; Liu, H. Changes in the expression of AQP4 and AQP9 in the hippocampus following Eclampsia-Like seizure. Int. J. Mol. Sci., 2018, 19(1), 19.
[PMID: 29351212]
[76]
Saadoun, S.; Papadopoulos, M.C.; Davies, D.C.; Krishna, S.; Bell, B.A. Aquaporin-4 expression is increased in oedematous human brain tumours. J. Neurol. Neurosurg. Psychiatry, 2002, 72(2), 262-265.
[http://dx.doi.org/10.1136/jnnp.72.2.262] [PMID: 11796780]
[77]
Saadoun, S.; Papadopoulos, M.C.; Watanabe, H.; Yan, D.; Manley, G.T.; Verkman, A.S. Involvement of aquaporin-4 in astroglial cell migration and glial scar formation. J. Cell Sci., 2005, 118(Pt 24), 5691-5698.
[http://dx.doi.org/10.1242/jcs.02680] [PMID: 16303850]
[78]
Warth, A.; Simon, P.; Capper, D.; Goeppert, B.; Tabatabai, G.; Herzog, H.; Dietz, K.; Stubenvoll, F.; Ajaaj, R.; Becker, R.; Weller, M.; Meyermann, R.; Wolburg, H.; Mittelbronn, M. Expression pattern of the water channel aquaporin-4 in human gliomas is associated with blood-brain barrier disturbance but not with patient survival. J. Neurosci. Res., 2007, 85(6), 1336-1346.
[http://dx.doi.org/10.1002/jnr.21224] [PMID: 17335082]
[79]
Suzuki, Y.; Nakamura, Y.; Yamada, K.; Kurabe, S.; Okamoto, K.; Aoki, H.; Kitaura, H.; Kakita, A.; Fujii, Y.; Huber, V.J.; Igarashi, H.; Kwee, I.L.; Nakada, T. Aquaporin positron emission tomography differentiates between grade III and IV human astrocytoma. Neurosurgery, 2018, 82(6), 842-846.
[http://dx.doi.org/10.1093/neuros/nyx314] [PMID: 28645205]
[80]
Nico, B.; Mangieri, D.; Tamma, R.; Longo, V.; Annese, T.; Crivellato, E.; Pollo, B.; Maderna, E.; Ribatti, D.; Salmaggi, A. Aquaporin-4 contributes to the resolution of peritumoural brain oedema in human glioblastoma multiforme after combined chemotherapy and radiotherapy. Eur. J. Cancer, 2009, 45(18), 3315-3325.
[http://dx.doi.org/10.1016/j.ejca.2009.09.023] [PMID: 19836227]
[81]
Ng, W.H.; Hy, J.W.; Tan, W.L.; Liew, D.; Lim, T.; Ang, B.T.; Ng, I. Aquaporin-4 expression is increased in edematous meningiomas. J. Clin. Neurosci., 2009, 16(3), 441-443.
[http://dx.doi.org/10.1016/j.jocn.2008.04.028] [PMID: 19153045]
[82]
Hiroaki, Y.; Tani, K.; Kamegawa, A.; Gyobu, N.; Nishikawa, K.; Suzuki, H.; Walz, T.; Sasaki, S.; Mitsuoka, K.; Kimura, K.; Mizoguchi, A.; Fujiyoshi, Y. Implications of the aquaporin-4 structure on array formation and cell adhesion. J. Mol. Biol., 2006, 355(4), 628-639.
[http://dx.doi.org/10.1016/j.jmb.2005.10.081] [PMID: 16325200]
[83]
Zhang, H.; Verkman, A.S. Evidence against involvement of aquaporin-4 in cell-cell adhesion. J. Mol. Biol., 2008, 382(5), 1136-1143.
[http://dx.doi.org/10.1016/j.jmb.2008.07.089] [PMID: 18708067]
[84]
Miyamoto, K.; Nagaosa, N.; Motoyama, M.; Kataoka, K.; Kusunoki, S. Upregulation of water channel aquaporin-4 in experimental autoimmune encephalomyeritis. J. Neurol. Sci., 2009, 276(1-2), 103-107.
[http://dx.doi.org/10.1016/j.jns.2008.09.014] [PMID: 18945445]
[85]
Li, L.; Zhang, H.; Verkman, A.S. Greatly attenuated experimental autoimmune encephalomyelitis in aquaporin-4 knockout mice. BMC Neurosci., 2009, 10, 94.
[http://dx.doi.org/10.1186/1471-2202-10-94] [PMID: 19660138]
[86]
Li, L.; Zhang, H.; Varrin-Doyer, M.; Zamvil, S.S.; Verkman, A.S. Proinflammatory role of aquaporin-4 in autoimmune neuroinflammation. FASEB J., 2011, 25(5), 1556-1566.
[http://dx.doi.org/10.1096/fj.10-177279] [PMID: 21257712]
[87]
Zelenina, M.; Zelenin, S.; Bondar, A.A.; Brismar, H.; Aperia, A. Water permeability of aquaporin-4 is decreased by protein kinase C and dopamine. Am. J. Physiol. Renal Physiol., 2002, 283(2), F309-F318.
[http://dx.doi.org/10.1152/ajprenal.00260.2001] [PMID: 12110515]
[88]
Detmers, F.J.; de Groot, B.L.; Müller, E.M.; Hinton, A.; Konings, I.B.; Sze, M.; Flitsch, S.L.; Grubmüller, H.; Deen, P.M. Quaternary ammonium compounds as water channel blockers. Specificity, potency, and site of action. J. Biol. Chem., 2006, 281(20), 14207-14214.
[http://dx.doi.org/10.1074/jbc.M513072200] [PMID: 16551622]
[89]
Huber, V.J.; Tsujita, M.; Yamazaki, M.; Sakimura, K.; Nakada, T. Identification of arylsulfonamides as Aquaporin 4 inhibitors. Bioorg. Med. Chem. Lett., 2007, 17(5), 1270-1273.
[http://dx.doi.org/10.1016/j.bmcl.2006.12.010] [PMID: 17178220]
[90]
Migliati, E.; Meurice, N.; DuBois, P.; Fang, J.S.; Somasekharan, S.; Beckett, E.; Flynn, G.; Yool, A.J. Inhibition of aquaporin-1 and aquaporin-4 water permeability by a derivative of the loop diuretic bumetanide acting at an internal pore-occluding binding site. Mol. Pharmacol., 2009, 76(1), 105-112.
[http://dx.doi.org/10.1124/mol.108.053744] [PMID: 19403703]
[91]
Kato, J.; Hayashi, M.K.; Aizu, S.; Yukutake, Y.; Takeda, J.; Yasui, M. A general anaesthetic propofol inhibits aquaporin-4 in the presence of Zn²⁺. Biochem. J., 2013, 454(2), 275-282.
[http://dx.doi.org/10.1042/BJ20130046] [PMID: 23772702]
[92]
Yang, W.C.; Zhou, L.J.; Zhang, R.; Yue, Z.Y.; Dong, H.; Song, C.Y.; Qian, H.; Lu, S.J.; Chang, F.F. Effects of propofol and sevoflurane on aquaporin-4 and aquaporin-9 expression in patients performed gliomas resection. Brain Res., 2015, 1622, 1-6.
[http://dx.doi.org/10.1016/j.brainres.2015.05.042] [PMID: 26100336]
[93]
Huber, V.J.; Tsujita, M.; Nakada, T. Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg. Med. Chem., 2009, 17(1), 411-417.
[http://dx.doi.org/10.1016/j.bmc.2007.12.040] [PMID: 18182301]
[94]
Li, X.; Liu, H.; Yang, Y. Magnesium Sulfate attenuates brain edema by lowering AQP4 expression and inhibits glia-mediated neuroinflammation in a rodent model of eclampsia. Behav. Brain Res., 2017.
[PMID: 29288747]
[95]
Wang, C.; Yan, M.; Jiang, H.; Wang, Q.; He, S.; Chen, J.; Wang, C. Mechanism of aquaporin 4 (AQP 4) up-regulation in rat cerebral edema under hypobaric hypoxia and the preventative effect of puerarin. Life Sci., 2018, 193, 270-281.
[http://dx.doi.org/10.1016/j.lfs.2017.10.021] [PMID: 29054452]
[96]
Tang, G.; Liu, Y.; Zhang, Z.; Lu, Y.; Wang, Y.; Huang, J.; Li, Y.; Chen, X.; Gu, X.; Wang, Y.; Yang, G.Y. Mesenchymal stem cells maintain blood-brain barrier integrity by inhibiting aquaporin-4 upregulation after cerebral ischemia. Stem Cells, 2014, 32(12), 3150-3162.
[http://dx.doi.org/10.1002/stem.1808] [PMID: 25100404]
[97]
Illarionova, N.B.; Gunnarson, E.; Li, Y.; Brismar, H.; Bondar, A.; Zelenin, S.; Aperia, A. Functional and molecular interactions between aquaporins and Na,K-ATPase. Neuroscience, 2010, 168(4), 915-925.
[http://dx.doi.org/10.1016/j.neuroscience.2009.11.062] [PMID: 19962432]
[98]
Tradtrantip, L.; Zhang, H.; Saadoun, S.; Phuan, P.W.; Lam, C.; Papadopoulos, M.C.; Bennett, J.L.; Verkman, A.S. Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica. Ann. Neurol., 2012, 71(3), 314-322.
[http://dx.doi.org/10.1002/ana.22657] [PMID: 22271321]
[99]
Chihara, N.; Aranami, T.; Sato, W.; Miyazaki, Y.; Miyake, S.; Okamoto, T.; Ogawa, M.; Toda, T.; Yamamura, T. Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica. Proc. Natl. Acad. Sci. USA, 2011, 108(9), 3701-3706.
[http://dx.doi.org/10.1073/pnas.1017385108] [PMID: 21321193]
[100]
Badaut, J.; Hirt, L.; Granziera, C.; Bogousslavsky, J.; Magistretti, P.J.; Regli, L. Astrocyte-specific expression of aquaporin-9 in mouse brain is increased after transient focal cerebral ischemia. J. Cereb. Blood Flow Metab., 2001, 21(5), 477-482.
[http://dx.doi.org/10.1097/00004647-200105000-00001] [PMID: 11333357]
[101]
Badaut, J.; Petit, J.M.; Brunet, J.F.; Magistretti, P.J.; Charriaut-Marlangue, C.; Regli, L. Distribution of Aquaporin 9 in the adult rat brain: preferential expression in catecholaminergic neurons and in glial cells. Neuroscience, 2004, 128(1), 27-38.
[http://dx.doi.org/10.1016/j.neuroscience.2004.05.042] [PMID: 15450351]
[102]
Amiry-Moghaddam, M.; Lindland, H.; Zelenin, S.; Roberg, B.A.; Gundersen, B.B.; Petersen, P.; Rinvik, E.; Torgner, I.A.; Ottersen, O.P. Brain mitochondria contain aquaporin water channels: evidence for the expression of a short AQP9 isoform in the inner mitochondrial membrane. FASEB J., 2005, 19(11), 1459-1467.
[http://dx.doi.org/10.1096/fj.04-3515com] [PMID: 16126913]
[103]
Badaut, J.; Brunet, J.F.; Petit, J.M.; Guérin, C.F.; Magistretti, P.J.; Regli, L. Induction of brain aquaporin 9 (AQP9) in catecholaminergic neurons in diabetic rats. Brain Res., 2008, 1188, 17-24.
[http://dx.doi.org/10.1016/j.brainres.2007.10.087] [PMID: 18053968]
[104]
Fan, Z.; Yuan, Y.; Wang, F.; Qi, Y.; Han, H.; Wu, J.; Zhang, G.; Yang, L. Diabetes mitigates the recovery following intracranial hemorrhage in rats. Behav. Brain Res., 2017, 320, 412-419.
[http://dx.doi.org/10.1016/j.bbr.2016.10.047] [PMID: 27818237]
[105]
Ribeiro, Mde.C.; Hirt, L.; Bogousslavsky, J.; Regli, L.; Badaut, J. Time course of aquaporin expression after transient focal cerebral ischemia in mice. J. Neurosci. Res., 2006, 83(7), 1231-1240.
[http://dx.doi.org/10.1002/jnr.20819] [PMID: 16511868]
[106]
Wu, H.; Tang, C.; Tai, L.W.; Yao, W.; Guo, P.; Hong, J.; Yang, X.; Li, X.; Jin, Z.; Ke, J.; Wang, Y. Flurbiprofen axetil attenuates cerebral ischemia/reperfusion injury by reducing inflammation in a rat model of transient global cerebral ischemia/reperfusion. Biosci. Rep., 2018, 38(4), 38.
[http://dx.doi.org/10.1042/BSR20171562] [PMID: 29540536]
[107]
Wang, B.F.; Cui, Z.W.; Zhong, Z.H.; Sun, Y.H.; Sun, Q.F.; Yang, G.Y.; Bian, L.G. Curcumin attenuates brain edema in mice with intracerebral hemorrhage through inhibition of AQP4 and AQP9 expression. Acta Pharmacol. Sin., 2015, 36(8), 939-948.
[http://dx.doi.org/10.1038/aps.2015.47] [PMID: 26119880]
[108]
Tan, G.; Sun, S.Q.; Yuan, D.L. Expression of the water channel protein aquaporin-9 in human astrocytic tumours: correlation with pathological grade. J. Int. Med. Res., 2008, 36(4), 777-782.
[http://dx.doi.org/10.1177/147323000803600420] [PMID: 18652774]
[109]
Warth, A.; Mittelbronn, M.; Hülper, P.; Erdlenbruch, B.; Wolburg, H. Expression of the water channel protein aquaporin-9 in malignant brain tumors. Appl. Immunohistochem. Mol. Morphol., 2007, 15(2), 193-198.
[http://dx.doi.org/10.1097/01.pai.0000213110.05108.e9] [PMID: 17525633]
[110]
Fossdal, G.; Vik-Mo, E.O.; Sandberg, C.; Varghese, M.; Kaarbø, M.; Telmo, E.; Langmoen, I.A.; Murrell, W. Aqp 9 and brain tumour stem cells. Scientif. World J., 2012., 2012915176
[http://dx.doi.org/10.1100/2012/915176] [PMID: 22262958]
[111]
Yang, M.; Gao, F.; Liu, H.; Yu, W.H.; Zhuo, F.; Qiu, G.P.; Ran, J.H.; Sun, S.Q. Hyperosmotic induction of aquaporin expression in rat astrocytes through a different MAPK pathway. J. Cell. Biochem., 2013, 114(1), 111-119.
[http://dx.doi.org/10.1002/jcb.24308] [PMID: 22886825]
[112]
Kunisawa, K.; Shimizu, T.; Kushima, I.; Aleksic, B.; Mori, D.; Osanai, Y.; Kobayashi, K.; Taylor, A.M.; Bhat, M.A.; Hayashi, A.; Baba, H.; Ozaki, N.; Ikenaka, K. Dysregulation of schizophrenia-related aquaporin 3 through disruption of paranode influences neuronal viability. J. Neurochem., 2018, 147(3), 395-408.
[http://dx.doi.org/10.1111/jnc.14553] [PMID: 30025158]
[113]
Zelenina, M.; Bondar, A.A.; Zelenin, S.; Aperia, A. Nickel and extracellular acidification inhibit the water permeability of human aquaporin-3 in lung epithelial cells. J. Biol. Chem., 2003, 278(32), 30037-30043.
[http://dx.doi.org/10.1074/jbc.M302206200] [PMID: 12773542]
[114]
Lambertz, N.; Hindy, N.E.; Adler, C.; Rump, K.; Adamzik, M.; Keyvani, K.; Bankfalvi, A.; Siffert, W.; Erol Sandalcioglu, I.; Bachmann, H.S. Expression of aquaporin 5 and the AQP5 polymorphism A(-1364)C in association with peritumoral brain edema in meningioma patients. J. Neurooncol., 2013, 112(2), 297-305.
[http://dx.doi.org/10.1007/s11060-013-1064-z] [PMID: 23392848]
[115]
Sveinsdottir, S.; Gram, M.; Cinthio, M.; Sveinsdottir, K.; Mörgelin, M.; Ley, D. Altered expression of aquaporin 1 and 5 in the choroid plexus following preterm intraventricular hemorrhage. Dev. Neurosci., 2014, 36(6), 542-551.
[http://dx.doi.org/10.1159/000366058] [PMID: 25342576]
[116]
Yang, J.; Zhang, J.N.; Chen, W.L.; Wang, G.S.; Mao, Q.; Li, S.Q.; Xiong, W.H.; Lin, Y.Y.; Ge, J.W.; Li, X.X.; Gu, Z.; Zhao, C.R. Effects of AQP5 gene silencing on proliferation, migration and apoptosis of human glioma cells through regulating EGFR/ERK/p38 MAPK signaling pathway. Oncotarget, 2017, 8(24), 38444-38455.
[http://dx.doi.org/10.18632/oncotarget.16461] [PMID: 28404978]
[117]
Zhu, S.J.; Wang, K.J.; Gan, S.W.; Xu, J.; Xu, S.Y.; Sun, S.Q. Expression of aquaporin8 in human astrocytomas: correlation with pathologic grade. Biochem. Biophys. Res. Commun., 2013, 440(1), 168-172.
[http://dx.doi.org/10.1016/j.bbrc.2013.09.057] [PMID: 24055034]
[118]
Morishita, Y.; Matsuzaki, T.; Hara-chikuma, M.; Andoo, A.; Shimono, M.; Matsuki, A.; Kobayashi, K.; Ikeda, M.; Yamamoto, T.; Verkman, A.; Kusano, E.; Ookawara, S.; Takata, K.; Sasaki, S.; Ishibashi, K. Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule. Mol. Cell. Biol., 2005, 25(17), 7770-7779.
[http://dx.doi.org/10.1128/MCB.25.17.7770-7779.2005] [PMID: 16107722]
[119]
Gorelick, D.A.; Praetorius, J.; Tsunenari, T.; Nielsen, S.; Agre, P. Aquaporin-11: a channel protein lacking apparent transport function expressed in brain. BMC Biochem., 2006, 7, 14.
[http://dx.doi.org/10.1186/1471-2091-7-14] [PMID: 16650285]
[120]
Koike, S.; Tanaka, Y.; Matsuzaki, T.; Morishita, Y.; Ishibashi, K. Aquaporin-11 (AQP11) Expression in the Mouse Brain. Int. J. Mol. Sci., 2016, 17(6), 17.
[http://dx.doi.org/10.3390/ijms17060861] [PMID: 27258268]

Rights & Permissions Print Cite
Article Metrics
55
4
1
Wayfinder Image
© 2024 Bentham Science Publishers | Privacy Policy