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Systematic Review Article

遗传变异与中东和北非地区大肠癌的关联：系统评价。

卷 20, 期 4, 2020

页: [286 - 298] 页: 13

弟呕挨: 10.2174/1566524019666191014170136

价格: $65

摘要

背景：结直肠癌（CRC）是全球第三大最常见的癌症，也是与癌症相关的死亡的第三大主要原因。它是通过不同的遗传和表观遗传机制发展的异质性疾病。迄今为止，尚未在扩展的MENA（eMENA）地区进行全面的系统研究，以调查家族性和散发性CRC的遗传危险因素。 目的：本研究旨在系统分析与eMENA地区CRC显着相关的遗传变异。 方法：从开始到2019年5月，我们使用广泛的搜索词搜索了四个文献数据库（PubMed，Scopus，Science Direct和Web of Science），以获取所有报告的与eMENA CRC患者相关的遗传数据。确定了OR> 1的与CRC相关的变体。 结果：从我们的检索方法中获得了1,200项研究，其中27项符合我们系统评价的纳入标准，共有8,230例CRC患者和7,611例对照。其中，发现在9个eMENA国家中分布的1,941名患者带有33个不同基因的46个变异体。有趣的是，eMENA地区的CRC患者有19种变异。 解释：这是第一个系统综述，目的是捕获与eMENA地区CRC显着相关的变异谱。 eMENA CRC患者的临床表现似乎与众不同，并且eMENA地区患者中变异的范围和分布与其他种族人群不同。

关键词: 大肠癌，遗传变异，基因型与表型的相关性，扩大的MENA区域，异质性疾病，CRC。

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