Title:Blood-brain Barrier Disruption May Contribute to White Matter Lesions in the Setting of Internal Jugular Venous Stenosis
Volume: 16
Issue: 4
Author(s): Yali Wu, Ran Meng, Gary B. Rajah, Yuchuan Ding, Yaoming Xu and Xunming Ji*
Affiliation:
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing,China
Keywords:
Internal Jugular Venous Stenosis (IJVS), blood-brain barrier, occludin, ZO-1, matrix metalloproteinase-9, white
matter lesions, neurological diseases.
Abstract:
Background and Purpose: Cloudy white matter lesions are associated imaging features
of internal jugular venous stenosis (IJVS). However, the mechanism of the IJVS associated cloudy
white matter lesions is still unclear. This study aims to evaluate blood-brain barrier integrity of the
patients with IJVS.
Materials and Methods: A total of 45 eligible patients with IJVS confirmed by computed tomography
venography (CTV) and 45 healthy controls were enrolled into this study. The levels of serum
MMP-9 and the markers of tight junctions, including occludin and ZO-1 obtained from IJVS
patients and control group were tested by enzyme-linked immune-sorbent assay and compared.
Results: Both the levels of serum MMP-9 (0.2ng/ml) and occludin (0.05ng/ml) in IJVS group were
higher than in the control group (0.01ng/ml vs. 0 ng/ml, all p<0.001). While, the levels of serum
ZO-1 showed no statistical significance between the two groups (0.55ng/ml vs 0.735ng/ml,
P=0.34). The levels of serum MMP-9 between the subset with or without white matter lesions in
IJVS group showed a significant difference (0.22 [0.06, 0.43] vs. 0.01 [0.01, 0.06], P =0.019).
Conclusion: BBB disruption may participate in the formation of IJVS-associated white matter lesions;
the mechanism of BBB disruption may involve MMP-9 and occludin.
