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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

玫瑰树碱及其衍生物：借助药物输送系统对临床适用性进行重新评估

卷 20, 期 1, 2020

页: [33 - 46] 页: 14

弟呕挨: 10.2174/1568009619666190927150131

价格: $65

摘要

有针对性的药物输送系统为安全，有效地使用治疗药物提供了新的尺寸，从而有助于规避毒性和意外药物积聚的问题。 递药系统的这些不断发展反过来又可以带回遭受各种局限性的药物，其中玫瑰树碱（EPT）是候选药物。 EPT衍生物已进入临床环境，但由于各种毒性副作用而未能在临床中幸存。 大量的临床前数据探讨了药物输送系统在提高EPT /衍生物效率同时降低其毒副作用方面的潜力。 药物输送系统的最新进展为探索EPT及其衍生物作为治疗肿瘤的良好临床候选药物提供了平台。 本文综述了EPT / EPT衍生物作为抗肿瘤药物的体内和体外传递机制，并评估了EPT载体在临床中的适用性。

关键词: 玫瑰树碱，衍生物，来源，抗癌活性，纳米载体，药物传递。

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图形摘要

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