Title:Prevention and Therapy of Prostate Cancer: An Update on Alternatives for Treatment and Future Perspectives
Volume: 15
Issue: 3
Author(s): Fernanda Majolo, Bruna Caye, Stefani Natali Stoll, Juliano Leipelt, Ana Lúcia Abujamra and Márcia Inês Goettert*
Affiliation:
- Laboratatório de Cultura de Células, Programa de Pós-Graduação em Biotecnologia, Universidade do Vale do Taquari – UNIVATES, Lajeado,Brazil
Keywords:
Prostate cancer, inflammation, natural products, treatment, biomarkers, docetaxel.
Abstract: Prostate cancer is one of the most prevalent cancer types in men worldwide. With the
progression of the disease to independent stimulation by androgen hormones, it becomes more difficult
to control its progress. In addition, several studies have shown that chronic inflammation is
directly related to the onset and progression of this cancer. For many decades, conventional chemotherapeutic
drugs have not made significant progress in the treatment of prostate cancer. However,
the discovery of docetaxel yielded the first satisfactory responses of increased survival of
patients. In addition, alternative therapies using biomolecules derived from secondary metabolites
of natural products are promising in the search for new treatments. Despite the advances in the
treatment of this disease in the last two decades, the results are still insufficient and conventional
therapies do not present the expected results they once promised. Thus, a revision and
(re)establishment of prostate cancer therapeutic strategies are necessary. In this review, we also
approach suggested treatments for molecular biomarkers in advanced prostate cancer.
