[1]
Siegel, R.L.; Miller, K.D.; Jemal, A. Cancer statistics. 2018. CA Cancer J. Clin., 2018, 68(1), 7-30.
[3]
Utku, N. New approaches to treat cancer - what they can and cannot do. Biotechnol. Healthc., 2011, 8(4), 25-27.
[4]
Bhardwaj, V.; Gumber, D.; Abbot, V.; Dhiman, S.; Sharma, P. Pyrrole: A resourceful small molecule in key medicinal hetero-aromatics. RSC Advances, 2015, 5, 15233-15266.
[5]
Mohamed, M.S.; Fathallah, S.S. Pyrroles and fused pyrroles: Synthesis and therapeutic activities. Mini Rev. Org. Chem., 2014, 11, 477-507.
[6]
Gholap, S.S. Pyrrole: An emerging scaffold for construction of valuable therapeutic agents. Eur. J. Med. Chem., 2016, 110, 13-31.
[7]
Pilli, R.A.; Rosso, G.B.; de Oliveira, M.C. The chemistry of stemona alkaloids: An update. Nat. Prod. Rep., 2010, 27(12), 1908-1937.
[8]
Itokawa, H.; Morris-Natschke, S.L.; Akiyama, T.; Lee, K.H. Plant-derived natural product research aimed at new drug discovery. J. Nat. Med., 2008, 62(3), 263-280.
[9]
Sun, L.; Veith, J.M.; Pera, P.; Bernacki, R.J.; Ojima, I. Design and synthesis of de novo cytotoxic alkaloids by mimicking the bioactive conformation of paclitaxel. Bioorg. Med. Chem., 2010, 18(19), 7101-7112.
[10]
Fiore, D.; Proto, M.C.; Pisanti, S.; Picardi, P.; Pagano Zottola, A.C.; Butini, S.; Gemma, S.; Casagni, A.; Laezza, C.; Vitale, M.; Ligresti, A.; Di Marzo, V.; Zisterer, D.M.; Nathwani, S.; Williams, D.C.; Campiani, G.; Gazzerro, P.; Bifulco, M. Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells. Cancer Biol. Ther., 2016, 17(8), 849-858.
[11]
Powell, R.G.; Weisleder, D.; Smith, C.R., Jr; Wolff, I.A. Structure of cephalotaxine and related alkaloids. Tetrahedron Lett., 1969, 10, 4081-4084.
[12]
Jaiash, D.A.; Belal, A.; Abdelgawad, M.A.; Abdellatif, K.R. Design, synthesis and biological evaluation of new pyrroloazepines with potential and selective antitumor activity. Acta Pol. Pharm., 2016, 73(2), 359-368.
[13]
Belal, A. Design, synthesis and anticancer activity evaluation of some novel pyrrolo[1,2-a]azepine derivatives. Arch. Pharm. (Weinheim), 2014, 347(7), 515-522.
[14]
Powell, R.G.; Weisleder, D.; Smith, C.R., Jr Antitumor alkaloids for Cephalataxus harringtonia: Structure and activity. J. Pharm. Sci., 1972, 61(8), 1227-1230.
[15]
Luo, C.Y.; Tang, J.Y.; Wang, Y.P. Homoharringtonine: a new treatment option for myeloid leukemia. Hematology, 2004, 9(4), 259-270.
[16]
Chanmahasathien, W.; Ohnuma, S.; Ambudkar, S.V.; Limtrakul, P. Biochemical mechanism of modulation of human P-glycoprotein by stemofoline. Planta Med., 2011, 77(18), 1990-1995.
[17]
Keri, R.S.; Patil, M.R.; Patil, S.A.; Budagumpi, S. A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry. Eur. J. Med. Chem., 2015, 89, 207-251.
[18]
Noolvi, M.N.; Patel, H.M.; Kaur, M. Benzothiazoles: Search for anticancer agents. Eur. J. Med. Chem., 2012, 54, 447-462.
[19]
Patel, R.V.; Patel, P.K.; Kumari, P.; Rajani, D.P.; Chikhalia, K.H. Synthesis of benzimidazolyl-1,3,4-oxadiazol-2ylthio-N-phenyl (benzothiazolyl) acetamides as antibacterial, antifungal and antituberculosis agents. Eur. J. Med. Chem., 2012, 53, 41-51.
[20]
Gillis, E.P.; Eastman, K.J.; Hill, M.D.; Donnelly, D.J.; Meanwell, N.A. Applications of fluorine in medicinal chemistry. J. Med. Chem., 2015, 58(21), 8315-8359.
[21]
Kumar, V.; Chimni, S.S. Recent developments on thiourea based anticancer chemotherapeutics. Anticancer. Agents Med. Chem., 2015, 15(2), 163-175.
[22]
Mistry, B.M.; Patel, R.V.; Keum, Y.S.; Kim, D.H. Chrysin-benzothiazole conjugates as antioxidant and anticancer agents. Bioorg. Med. Chem. Lett., 2015, 25(23), 5561-5565.
[23]
Brand-Williams, W.; Cuvelier, M.E.; Berset, C. Use of a free radical method to evaluate antioxidant activity. Lebensm. Wiss. Technol., 1995, 28, 25-30.
[24]
Mensor, L.L.; Menezes, F.S.; Leitão, G.G.; Reis, A.S.; dos Santos, T.C.; Coube, C.S.; Leitão, S.G. Screening of Brazilian plant extracts for antioxidant activity by the use of DPPH free radical method. Phytother. Res., 2001, 15(2), 127-130.
[25]
Re, R.; Pellegrini, N.; Proteggente, A.; Pannala, A.; Yang, M.; Rice-Evans, C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic. Biol. Med., 1999, 26(9-10), 1231-1237.
[26]
Adaramoye, O.A.; Sarkar, J.; Singh, N.; Meena, S.; Changkija, B.; Yadav, P.P.; Kanojiya, S.; Sinha, S. Antiproliferative action of Xylopia aethiopica fruit extract on human cervical cancer cells. Phytother. Res., 2011, 25(10), 1558-1563.
[27]
Pang, Y.N.; Liang, Y.W.; Feng, T.S.; Zhao, S.; Wu, H.; Chai, Y.S.; Lei, F.; Ding, Y.; Xing, D.M.; Du, L.J. Transportation of berberine into HepG2, HeLa and SY5Y cells: A correlation to its anti-cancer effect. PLoS One, 2014, 9(11)e112937
[28]
Jacobs, W.A.; Heidelberger, M. The ferrous sulfate and ammonia method for the reduction of nitro to amino compounds. J. Am. Chem. Soc., 1917, 39, 1435-1439.
[29]
Sayed, S.M.; Raslan, M.A.; Dawood, K.M. Synthesis and reactivity of phenylthiourea derivatives: An efficient synthesis of new thiazole-based heterocycles. J. Heterocycl. Chem., 2016, 53, 508-512.
[30]
Wang, L.; Li, P.; Li, B.; Wang, Y.; Li, J.; Song, L. Design, synthesis, and antitumor activity of novel quinazoline derivatives. Molecules, 2017, 22(10), 1624.
[31]
Azzariti, A.; Porcelli, L.; Xu, J-M.; Simone, G.M.; Paradiso, A. Prolonged exposure of colon cancer cells to the epidermal growth factor receptor inhibitor gefitinib (Iressa(TM)) and to the antiangiogenic agent ZD6474: Cytotoxic and biomolecular effects. World J. Gastroenterol., 2006, 12(32), 5140-5147.
