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Review Article

基于病毒和宿主因素的针对乙肝病毒的潜在药物靶标

卷 20, 期 16, 2019

页: [1636 - 1651] 页: 16

弟呕挨: 10.2174/1389450120666190729115646

价格: $65

摘要

背景：乙型肝炎是由乙型肝炎病毒（HBV）引起的非常有害的流行病。尽管可获得有效的抗HBV疫苗，但慢性感染仍然在全世界构成巨大的健康负担。本发明的抗HBV药物包括核苷类似物和干扰素α，无一例外具有其局限性。到目前为止，还没有有效的药物和治疗方法可以真正，真正地治愈乙型肝炎。 HBV基因组的变异性导致大量患者在长期使用抗HBV药物时产生耐药性。因此，迫切需要发现新的靶标并开发抗乙型肝炎的新药。 目的：本综述旨在通过总结抗病毒潜在靶标的现状，为抗乙肝病毒创新药物的设计提供理论支持。 结果与结论：由于HBV是专性的细胞内寄生虫，因此它依赖宿主细胞的成分和功能来自我复制。同时靶向病毒和宿主可能是乙型肝炎的一种新型治疗选择。因此，我们分析了抗HBV感染的潜在药物靶点的研究进展，重点是靶向病毒基因组，靶向宿主细胞功能和靶向病毒与宿主蛋白的相互作用分别。同时，还强调了针对慢性乙型肝炎的免疫靶标。简而言之，该综述总结了针对病毒因子，宿主因子和免疫因子的抗病毒治疗策略，以便将来设计针对HBV感染的创新药物。

关键词: 乙肝病毒，病毒靶标，宿主靶标，病毒-宿主相互作用，免疫靶标，药物设计。

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