This reference provides an update on current therapies to treat neglected diseases, a class of diseases that primarily affect tropical regions where investment in research and development is limited. The book starts with an introduction to neglected diseases followed by reviews of therapeutic strategies to overcome the impact of neglected diseases. This is followed by updated information for handling leprosy, dengue, lymphatic filariasis, dracunculiasis, helminthiasis, Chagas’ disease, neurocysticercosis, leishmaniasis, rabies, trematodiasis, buruli ulcer and trachoma in 10 focused chapters, respectively. The chapters provide information on disease mechanism, transmission and management protocols, along with scientific references. The book serves as a resource for healthcare professionals, and scholars who need a detailed understanding of these infectious diseases.

Precision Medicine and Human Health covers several aspects of precision medicine in 20 edited reviews by researchers and healthcare professionals. The breadth of information provided by the contributors aims to familiarize readers with basic and applied research in personalized therapy. Starting with an overview of the subject and its relationship with epigenetics, the book progresses into advanced topics that explain its wider applications. The use of precision medicine in treating different diseases such as protein misfolding disorders, gut ulcers and their effect on the gut microbiome, cancer treatment (for hepatocellular carcinoma, breast cancer, and oral cancer), fibromyalgia, high altitude sickness, and multiple sclerosis is explained. The book also covers modern therapeutic techniques to administer personalized therapy, including epithelial-mesenchymal therapy (EMT), circadian clock modulation, and artificial intelligence and phytoconstituents. The next chapters cover advanced technologies that are crucial to precision medicine, such as nanomaterials and advanced drug delivery systems. A concluding chapter on the therapeutic use of tannins in precision medicine rounds up the contents. Key Features: - Features 20 focused chapters contributed by scientific experts - Introduces readers to basic concepts in precision medicine - Covers the application of precision medicine in treating different diseases - Showcases several techniques used in experimental and clinical precision therapy - Explains modern technologies in precision medicine - Caters to a wide readership with introductions, structured headings, and references This is an informative reference for healthcare professionals in clinics and hospitals and any scholar who wants to learn about basic and applied knowledge in precision medicine.

This book summarizes the cutting-edge experimental research on heterocyclic compounds used as anti-inflammatory agents in ten chapters. Each chapter is authored by experts in medicinal chemistry and is supplemented with scientific references for advanced reading. The book covers several types of heterocyclic compounds and their derivatives including : - pyrimidine and pyrimidinone derivatives - 1,2,3, and 1,2,4 triazoles - imidazole and benzimidazole derivatives - oxazole, oxadiazole, isoxazoline, and oxazoline derivatives - thiazole and thiazolidinone derivatives - pyrazole and pyrazoline - Carbazoles and their derivatives - azipines, quinolines, and coumarins This is a timely reference for medicinal chemists interested in developing new heterocycles for anti-inflammatory drugs. Contributors have discussed the effects of these compounds on different types of inflammation and their evolution in drug development as therapeutic agents to give a wider perspective to readers.

In nature lies the solution to restore teeth with minimal damage. In this groundbreaking book, the management of dental challenges is presented from a new perspective. Natural Conservative Dentistry: An Alternative Approach to Solve Restorative Problems provides evidence-based solutions to dental challenges to researchers, practitioners and dental service providers. The main attribute of all these solutions is that they are all derived from natural ingredients. Natural ingredients are an effective alternative for dental care and management in contrast to synthetic products that have multiple side effects. This book fills a knowledge gap on alternative and sustainable solutions derived from nature to respond effectively to dental challenges encountered in dental treatment for the conservation of the tooth. It is a compilation of the work of expert dentists that has been carried out in clinics for the management of dental problems. Key Features - Provides an insightful look at the prevention of dental diseases through evidence-based interventions using natural products in 9 referenced chapters - Contains valuable contributions in restorative dentistry, such as caries prevention, enamel and dentin remineralization, dentin biomodification, dentin desensitization, vital pulp therapy, antioxidants, and tooth bleaching - Provides an update on the current status of different ingredients used in oral health care products developed for commercial markets - Includes notes on pathophysiology and diagnosis on specific conditions and sources of natural ingredients The book is a valuable reference for trainees and professionals who want to enhance their restorative dentistry practice in the clinic.

Geriatric Anesthesia: A Practical Guide is a comprehensive reference on geriatric anesthesia. The book is divided into three sections. The first section covers the basics of both anatomical and physiological changes in senescence, and important polypharmacy considerations common in elderly patients. The next section covers anesthesia for cardiac and non-surgical patients. Various controversies and legal ethical issues that are particularly significant in the elderly such as advance directives, code status discussions, specific patient groups and shared decision-making prior to surgical interventions, are covered in the final section. Key features - 20 referenced chapters covering basic geriatric anesthesia considerations, cardiac and non-surgical patients and special topics, respectively - Contributions and references from experienced anesthesiologists - Emphasis on tailoring perioperative management depending on specific circumstances of patients - Addresses novel and commonly overlooked topics related to the geriatric population This book is a guide for both anesthesia providers and non-anesthesia medical providers, trainees and students. It equips them with necessary information to understand and devise anesthetic plans while being aware of postoperative complications and the respective treatment and management options.

Drug Addiction Mechanisms in the Brain explores the fascinating world of drug substances and their effects on the brain. This book provides a comprehensive overview of the ten major substances that contribute to drug addiction Information about each substance is presented in a specific chapter, shedding light on their biochemical mechanisms and physiological effects. From the stimulating effects of cocaine to the sedative properties of heroin, and the hallucinogenic experiences induced by LSD, the book takes the reader through the intricate pathways of addiction. Other substances covered in the book include alcohol, nicotine, MDMA, METH, morphine, ketamine, and fentanyl. Readers will gain an understanding about neurochemical alterations in the brain Anyone looking for interesting knowledge about the addictive nature of common drugs and their complex interplay with the brain will find this book informative.

Textbook of Advanced Dermatology: Pearls for Academia and Skin Clinics is an essential reference for practicing dermatologists in hospitals and clinics. The book aims to provide interesting tips that cannot be found in traditional dermatology handbooks. The contributors include top minds in dermatology and related fields such as Joe Niamtu, Samuel Lam, and Steven Feldman. Topics in the book include novel, original formulations for topical compounds, ways to improve patient adherence to prescriptions, business tips, novelties in skin surgery, and solutions for preventing patient complaints and legal suits. The book also highlights the author's personal experiences gained over many years in improving everyday clinical dermatology practice. The book is divided into 5 sections each representing 'pearls' of advice: Teaching Pearls, Medical Pearls, Publication Pearls, Procedural Pearls, and Business Pearls, encompassing all of the broad realm of dermatology.

Inflammation triggers specific metabolic pathways and if not resolved, translates into several painful diseases such as rheumatoid arthritis, lupus, Alzheimer's disease, cardiovascular disorders and psoriasis. Various processes have been explored to understand the factors behind inflammation and consequently, many mechanisms have been examined to suppress it. The nucleotide-binding domain like receptor 3 (NLRP3) inflammasome is an example of such factors which is responsible for triggering sterile and microbe induced inflammation. Studies of genetic variants of the related gene have revealed insights into the mRNA expression pathways that may help researchers to identify crucial disease mechanisms. This book is a review of the scientific findings of distinguished scholars who have studied NLRP3 inflammasome activation and its contribution in worsening the outcomes of inflammatory disorders. This collection of chapters covers many aspects of the multifaceted role of NLRP3 inflammasome. Beginning with airway inflammation and fibrosis, it progresses to explore its involvement in pulmonary hypertension, heart diseases, tuberculosis, cardiovascular complications, and childhood asthma. Additionally, it examines the inflammasome's impact on protozoan parasitic infections and neuropathic pain. The chapters not only elucidate the intricate mechanisms of NLRP3 activation but also discuss potential inhibitors and therapeutic targets. Readers will gain a comprehensive understanding of the NLRP3 inflammasome's diverse implications across different physiological contexts. The book includes references making this book a valuable treatise of insights for researchers, clinicians, and healthcare professionals.

Software and Programming Tools in Pharmaceutical Research is a detailed primer on the use for computer programs in the design and development of new drugs. Chapters offer information about different programs and computational techniques in pharmacology. The book will help readers to harness computer technologies in pharmaceutical investigations. Readers will also appreciate the pivotal role that software applications and programming tools play in revolutionizing the pharmaceutical industry. The book includes nine structured chapters, each addressing a critical aspect of pharmaceutical research and software utilization. From an introduction to pharmaceutical informatics and computational chemistry to advanced topics like molecular modeling, data mining, and high-throughput screening, this book covers a wide range of topics. Key Features: - Practical Insights: Presents practical knowledge on how to effectively utilize software tools in pharmaceutical research. - Interdisciplinary Approach: Bridges the gap between pharmaceutical science and computer science - Cutting-Edge Topics: Covers the latest advancements in computational drug development, including data analysis and visualization techniques, drug repurposing, pharmacokinetic modelling and screening. - Recommendations for Tools: Includes informative tables for software tools - Referenced content: Includes scientific references for advanced readers The book is an ideal primer for students and educators in pharmaceutical science and computational biology, providing a comprehensive foundation for this rapidly evolving field. It is also an essential resource for pharmaceutical researchers, scientists, and professionals looking to enhance their understanding of software tools and programming in drug development.

Morphea and Related Disorders is a comprehensive reference on morphea. The book covers the subject in 20 chapters. The book starts with a detailed introduction and history of the morphea and its various classifications systems. Next, the book progresses into epidemiology, predisposing factors and pathogenic mechanisms, followed by histopathology for morphea diagnosis and a detailed review of clinical presentations. Subsequent chapters cover associated diseases and extracutaneous manifestations, medical investigations, treatment guidelines and special topics (Idiopathic atrophoderma of Pasini and Pierini, Linear atrophoderma of Moulin, Parry-Romberg syndrome, Lichen sclerosus, pediatric morphea and eosinophilic fasciitis). Key features: -he most detailed reference book on morphea -Easy and simple language for readers -Chapter synopsis at the beginning of each chapter -Learning points at the end of the chapter -More than 100 high resolution colored photographs -Information boxes and tables to enhance readability. -Covers basic knowledge on morphea, including pathogenesis, clinical presentations, and classification -Includes guidelines for professionals -Includes chapters on special topics for advanced readers Morphea and Related Disorders is the definitive reference book for medical students, residents, instructors, and physicians.