This comprehensive compendium unravels the intricacies of three common and daunting skeletal disorders: osteoporosis, osteoarthritis, and rheumatoid arthritis. These ailments afflict people across all age groups, demanding a deeper understanding of their diagnostic, prognostic, preventive, and therapeutic dimensions. It presents seven key topics written by medical experts that explore research on these diseases: Chronic Lung Disease and Osteoporosis An exploration of the intricate link between chronic lung ailments and osteoporosis. AI Detection of Knee Osteoarthritis Recent use of artificial intelligence aiding knee osteoarthritis identification. Inflammatory Signalling in Rheumatoid Arthritis Covers the role of cytokines and chemokines in the context of rheumatoid arthritis. Vitamin D, Immune System, and Bone Health Unveils the vital implications of Vitamin D on the immune system and bone health. Bone Water and Hydration Effects A review of the impact of drugs on bone hydration status through the lens of bone water. Dietary Patterns and Rheumatoid Arthritis An analysis of the connection between dietary habits and rheumatoid arthritis. Quality of Life in Rheumatoid Arthritis Patients (Chapters 112-130): An examination of the self-perceived quality of life in Rheumatoid Arthritis patients, comparing South Asian and British White populations. This knowledge-rich treatise is a valuable resource for patients and their families battling these skeletal ailments. It's equally beneficial for medical students, orthopedists, researchers, and anyone eager to grasp the complexities of these widespread skeletal pathologies.

Nanotechnology has shown immense promise for advancing blood glucose control. This technology offers the potential to safeguard pancreatic cells from autoimmune destruction by driving the creation of innovative therapeutic agents that can be delivered to specific targets. In this book, you will find a comprehensive exploration of diabetes and its approved medical treatments. The book delves into how nanotechnology can amplify the efficacy of current treatment modalities, potentially paving the way for a gene therapy solution to combat this disease. Starting with the history of diabetes treatment, the book explains treatment challenges for diabetes before getting into the three ways nanoscience is helping in diabetes treatment: insulin delivery, drug delivery and nucleotide delivery. Each chapter is contributed by accomplished experts in their respective fields, who strive to offer a thorough, yet accessible discussion of the subject.

This handbook covers Optical Coherence Tomography Angiography (OCT-A) with a specific focus on choroidal and vitreoretinal disorders. It serves as an invaluable resource for teaching and aiding daily clinical decision-making in the field. Book chapters dissect the fundamentals of angiography through OCT, offering guidance on OCT-A and insights into macular perfusional findings across various vitreoretinal and choroidal pathologies. From diabetic retinopathy to autoimmune diseases and neovascularization, the book addresses prevalent vascular entities encountered in routine practice. Furthermore, it explores innovative approaches, including antivascular endothelial growth factor molecules and extended-release delivery devices, contributing significantly to the diagnostic and decision-making processes in clinical and surgical retina care. Each chapter is contributed by experts in the relevant subspecialty. Key Features: Practical, patient-centered guide emphasizing a clinical approach. Demonstrative clinical cases for enhanced understanding. Evaluation of perfusional indices using noninvasive and noncontact imaging techniques. High histopathological correlation of structural tissue characterization with microvascular evaluation. Exploration of new perfusion concepts and their role in disease pathogenesis. Part 2 covers advanced topics in OCT-A for choroidal and vitreoretinal disorders. Chapters explore macular perfusional repercussions in obstructive venous vascular phenomena, OCT-A findings in retinal infarction, and the role of macular perfusion in myopic macular traction maculopathy. Further discussions include postoperative perfusional findings in vitreoretinopathy, distinctions in choroidal vasculopathies, and the application of OCT-A in managing pathological choroidal neovascularization. The part concludes with a review of postoperative membrane formation, the usefulness of OCT-A in neurodegenerative diseases, and the evaluation of arterial occlusions and choroidal neovascularization management.

Alzheimer’s disease (AD) is currently recognized as an untreatable, progressive, degenerative and terminal disease that is globally afflicting an estimated 36 million people and this number is growing in an unabated and frightening manner. Advances in Alzheimer Research, provides researchers with an integrated approach to AD academic literature ranging from basic to advanced clinical research. The series highlights the latest information in order to unravel the origin, pathogenesis and prevention of AD. The purpose of this book series is, therefore, to capture and discuss both, improvements towards the diagnosis and potential treatment of AD by established and novel strategies. This first volume of the series provides an important mechanism to bring individuals having a variety of scientific interests and expertise under one roof to specifically focus on AD and related dementias. This volume presents articles on beta amyloid protein targets as well as research on secretase enzyme systems among other topics that deal with AD therapy.

Alzheimer’s disease (AD) is currently recognized as an untreatable, progressive, degenerative and terminal disease that is global – afflicting over 36 million people worldwide, with the number growing in an unabated and frightening manner. The goal of the series Advances in Alzheimer’s Research , with Volumes 1 and 2, is to provide an integrated approach to AD from basic and clinical research and to highlight the valuable information in order to unravel the origin, pathogenesis and prevention of AD. The aim of this book is to both capture and discuss improvements toward the diagnosis and potential treatment of AD by both established and novel strategies. This book series, including the Volume 2, provides an important mechanism to bring under the same roof a variety of scientific interests and expertise to specifically focus on AD and related dementias. The fullest attempt has been made to disseminate the most current knowledge on recent advances in potential therapy of AD.

Stem cells with self-renewal and multi-lineage differentiation potential have potential for developing medicines for a range of refractory and recurrent disease. This book mainly focuses on the landscape of the biological properties and translational research of stem cells types, including hematopoietic stem cells (HSCs), neural stem cells (NSCs) and mesenchymal stem/stromal cells (MSCs). The book also introduces readers to the current updates and development prospects of stem cells in singular or combination therapies with advanced biomaterials and technological innovations towards large-scale standardization and productization. Key Features: - Introduces readers to stem cell biology and tissue engineering - Covers innovations in stem cell therapy and biomaterials - Includes a brief guide to commercialization of stem cell technology - Includes references for advanced readers The contents will strengthen the reader’s understanding of stem cell-based therapies. This book is a primer on stem cell and regenerative medicine for a wide readership including students, healthcare professionals, researchers and general readers.

Contemporary Endoscopic Spine Surgery brings the reader the most up-to-date information on the endoscopy of the spine. Key opinion leaders from around the world have come together to present the clinical evidence behind their competitive endoscopic spinal surgery protocols. Chapters in the series cover a range of aspects of spine surgery including spinal pain generators, preoperative workup with modern independent predictors of favorable clinical outcomes with endoscopy, anesthesia in an outpatient setting, management of complications, and a fresh look at technology advances in a historical context. The reader will have a first-row seat during the illustrative discussions of expanded surgical indications from herniated disc to more complex clinical problems, including stenosis, instability, and deformity in patients with advanced degenerative disease of the human spine. Contemporary Endoscopic Spine Surgery is divided into three volumes: Cervical Spine, Lumbar Spine, and Advanced Technologies to capture an accurate snapshot in time of this fast-moving field. It is intended as a comprehensive go-to reference text for surgeons in graduate residency and postgraduate fellowship training programs and for practicing spine surgeons interested in looking for the scientific foundation for their practice expansion into endoscopic surgery. This volume (Lumbar Spine) covers the following topics in 18 detailed chapters: Lumbar endoscopy: historical perspectives, present, and future Endoscopic lumbar discectomy - anatomy, nomenclature, indications and advanced techniques Current approaches for the treatment of endstage vacuum degenerative lumbar disc disease Advanced endoscopic techniques of lumbar foraminotomy and treatment of degenerative spondylolisthesis Endoscopic treatment of lumbar facet cysts Endoscopic techniques for the treatment of a wide range of chronic low back pain Endoscopic spine surgery techniques in the elderly Endoscopic fusion techniques Endoscopic resection of schwannoma Technical notes for difficult cases, controversies and complications of lumbar endoscopy.

Nanomedicine is evolving with novel drug formulations devised for multifunctional approaches towards diagnostics ad therapeutics. Nanomedicine-based drug therapy is normally explored at a fixed dose. The drug action is time-dependent, dose-dependent and patient-specific. To overcome challenges of nanomedicine testing, artificial intelligence (AI) serves as a helping tool for optimizing the drug and dose parameters. Real time conversions between these two features enables upgradation of patient data acquisition and improved design of nanomaterials. In this scenario, AI-based pattern analysis and algorithms models can greatly improve accuracy of diagnostics and therapeutics. This book gives a comprehensive explanation of the role of machine learning and artificial intelligence in cancer nanomedicine. It presents 10 chapters that cover multiple dimensions of the subject. These dimensions are: - The need of AI and ML in designing new cancer drugs - Application of AI in cancer drug design - AI-based drug delivery models for cancer drugs - Diagnostic applications of AI - Intelligent nanosensors for biomarker profiling - Predictive models for metastatic cancer - Cancer nanotheranostics - Ethics of AI in medicine Contributions have been made by 16 researchers who are experts in pharmacology and drug design. The contents of the book bridge knowledge gaps between the fields of biomedical engineering, pharmacology and clinical medicine, with a focus on cancer treatment. The book serves as a reference for scholars learning about cancer diagnostics and therapeutics. Biomedical engineers who are involved in healthcare projects will also find the concepts and techniques highlighted in the book informative for understanding modern computer-based approaches used to solve clinical problems.

Colorectal Cancer is a complex disease caused by the interaction of hereditary and environmental factors that can be classified based on their importance. Colorectal Cancer Diagnosis and Therapeutic Updates provides comprehensive information about the diagnosis and treatment of colorectal cancer. Chapters first cover the fundamentals of colorectal cancer diagnosis, progressing further towards explaining therapeutic modalities and recent advances in the understanding of the disease. Key Features - 11 organized, reader-friendly chapters that provide a complete overview of colorectal cancer - Covers the colorectal cancer diagnosis, screening and histopathology - Covers multimodal treatment of colorectal cancer, including chemotherapy, radiotherapy and robotic surgery - Covers the management and surveillance of colorectal cancer - Explains the key biochemical mechanisms involved in colorectal cancer treatment - Covers recent information about colorectal cancer theranostics and drug delivery - Includes references for further reading in every chapter. The book serves as an introductory reference for medical students and residents on the subject of colorectal cancer. It also serves as a quick reference on the disease for the practicing general physician.

Diabesity refers to the linkage of both diabetes and obesity that results in the coexistence of these 2 conditions. Research has identified pathophysiological mechanisms revolving around insulin resistance and hyperinsulinemia. Diabesity has important diagnostic and therapeutic implications. This book is a multidisciplinary review of diabesity. It highlights the various pharmacological methods of managing the condition. The book presents 10 chapters contributed by more than 40 experts from around the world. The review starts with an overview of diabesity and progressively describes the relationships of diabesity with the choice of diets and psychological factors. The chapters then cover the role of adipokines as therapeutic biomarkers before presenting research on medicinal and nutritional approaches to treat the condition. Modern approaches to diabesity treatment such as the use of new bioactive phytochemicals, mitigating meta-inflammation and laboratory techniques are also reviewed in the book. Diabesity: A Multidisciplinary Approach is a timely reference for clinicians (in endocrinology and family medicine subspecialties) and students of pharmacology and medicinal chemistry on the intricate relationship between diabetes and obesity.