Frontiers in Natural Product Chemistry is a book series devoted to important advances in natural product chemistry. The series features volumes that cover all aspects of research in the chemistry and biochemistry of naturally occurring compounds, including research on natural substances derived from plants, microbes and animals. Reviews of structure elucidation, biological activity, organic and experimental synthesis of natural products as well as developments of new methods are also included in the series. Volume 11 of the series brings together 5 reviews: - Medicinal importance of turmeric (curcuma longa) and its natural products - Novel natural compounds for hepatocellular carcinoma treatment - Herbal drug substitution (abhava-pratinidhi dravya): a key to stopping economic adulteration of botanical ingredients - Synthetic and natural agents as bacterial biofilm inhibitors - Quercetin chemistry, structural modifications, SAR studies and therapeutic applications: an update

This book describes nuclear magnetic resonance (NMR) methods which are used to study translational dynamics of molecules in different complex systems including systems made of synthetic and natural polymers, tissues and the porous heterogeneous systems of different types, such as cement and wood. The results of proton spin-lattice and spin-spin relaxation, cross-relaxation, pulse field gradient (PFG) NMR in studying diffusion properties and dynamics of molecules in polymer systems of different complexity are reported. In addition to these methods, reports on the use of the double-quantum-filtered (DQF) NMR technique in a study of slow molecular dynamics and properties of systems with anisotropic properties, such as water in hardening cement pastes, are presented. The book also covers applications of one and two dimensional NMR techniques. This book is a useful reference for readers learning different NMR techniques and their applications in civil engineering and biochemistry.

Medicinal and Environmental Chemistry: Experimental Advances and Simulations is a collection of topics that highlight the use of pharmaceutical chemistry to assess the environment or make drug design and chemical testing more environment friendly. The ten chapters included in the first part of this book set cover diverse topics, blending the fields of environmental chemistry and medicinal chemistry and have been authored by experts, scientists and academicians from renowned institutions. The book introduces the reader to environmental contaminants and techniques for their quantification and removal. A medicinal perspective for effects and remediation of environmental hazards, and therapeutic strategies available to design new and safer drugs, is addressed with a focus on knowledge about experimental and simulation methods. To further elaborate the importance of environmentally safe chemical practice, the concept of green chemistry has also been covered. Specialized chapters have been included in the book about persistent organic pollutants, heavy metal and plastic pollutants, the effect of environmental xenoesterogens on human health and the potential of natural products to combat ecotoxicity. Key Features: 1. 10 topics which blend environmental chemistry and medicinal chemistry 2. Contributions from more than 30 experts 3. Includes introductory topics on environmental pollutants, investigative techniques in drug design and environmental risk assessment and green chemistry 4. Includes specialized topics on persistent pollutants, ecotoxicity remediation and xenoestrogens 5. Bibliographic references This reference is an essential source of information for readers and scholars involved in environmental chemistry, pollution management and pharmaceutical chemistry courses at graduate and undergraduate levels. Professionals and students involved in occupational medicine will also benefit from the wide range of topics covered.

Medicinal and Environmental Chemistry: Experimental Advances and Simulations is a collection of topics that highlight the use of pharmaceutical chemistry to assess the environment or make drug design and chemical testing more environment friendly. The eleven chapters included in the second part of this book set cover diverse topics, blending the fields of environmental chemistry and medicinal chemistry and have been authored by experts, scientists and academicians from renowned institutions. This part is more specialized in nature, focusing primarily on the effects of air pollution and water contamination on human health. Chapters covering pharmaceutical interventions and pollution control measures, respectively follow these initial topics. Part II also features specialized topics that aim to address some unique challenges of the above mentioned problems including antibiotic pollution, pharmaceutical analysis of pollutants, chemosensors, biosteric modifications and new drug development strategies against SARS-CoV2. Key Features: 1. 11 topics which blend environmental chemistry and medicinal chemistry 2. Contributions from more than 40 experts 3. Includes topics covering effects of air pollution on human health and disease 4. Includes specialized topics on pharmaceutical analysis in the environment, and modifications of compounds for pharmaceutical purposes 5. Bibliographic references This reference is an essential source of information for readers and scholars involved in environmental chemistry, pollution management and pharmaceutical chemistry courses at graduate and undergraduate levels. Professionals and students involved in occupational medicine will also benefit from the wide range of topics covered.

Medicinal Chemistry - Fusion of Traditional and Western Medicine is a textbook intended for students taking courses in the various fields of medicinal chemistry, pharmacy, medical and dental programs. Moreover, people working in the pharmaceutical industry and doctors preparing for Medical Board Exams will also find it useful. Since, new drugs are being developed by multi-disciplinary teams; this E-Book describes new paradigms that are emerging in modern biology, biochemistry and medicine. It is therefore a fusion of traditional and western medicine and between systems thinking and reductionist thinking. Readers will learn about how new drugs are investigated, developed and eventually approved by the FDA. The book also includes important information about cGMP, GLP and the FDA regulatory requirements, the importance of environmental toxins, such as bisphenol A (BPA) and perfluorooctanoic acid (PFOAA) in autoimmune diseases and health. This book offers exceptional value in its descriptions of RNA, epigenetics, toxicology, new drug development, genetically modified organisms and analytical chemistry that cannot be found in other textbooks.

Medicinal Chemistry - Fusion of Traditional and Western Medicine is a textbook intended for students taking courses in the various fields of medicinal chemistry, pharmacy, medical and dental programs. Moreover, people working in the pharmaceutical industry and doctors preparing for Medical Board Exams will also find it useful. Since, new drugs are being developed by multi-disciplinary teams; this E-Book describes new paradigms that are emerging in modern biology, biochemistry and medicine. It is therefore a fusion of traditional and western medicine and between systems thinking and reductionist thinking. The 3rd edition attempts to explain the predictive, preventive, personalized and participatory (P4) paradigm of medicinal chemistry. This edition features new chapters focusing on personalized medicinal chemistry and the endocrine system (with a discussion of bioidentical hormone therapy). Other chapters cover the disease mechanism and associated pharmacology of drugs for several diseases including cancer, metabolic syndrome, diabetes, heart disease, stroke, osteoporosis, neurodegenerative diseases, the immune system and much more. The new edition also includes an overview of emergent medical problems and possible solutions (such as the flu, ebola virus, global climate change, a shortage of medicines, genetic engineering and stem cell therapy). Drugs that have been approved by the FDA since the 1st edition was written are also included. The book concludes with an explanation of systems thinking in medicinal chemistry, an important, yet rarely explored topic in other medicinal chemistry text books.

This eBook covers the application of high-throughput R&D to both fundamental and applied catalysis including catalyst synthesis, characterization, and testing in various reactor types. Chapters include topics such as applications ranging from optimizations of established industrial catalysts to the discovery of innovative new materials, examples of the development of innovative parallel characterization methods, and cases of real catalyst testing in small scale reactor systems. Readers will also find chapters that cover commodity chemicals produced using continuous gas phase processes as well as fine chemicals produced in liquid phase batch reactors. The potential of industrial chemicals production from biorenewable feedstocks is also presented. The steadily improving high throughput workflows are today being applied to relevant reactions and targets such as hydrotreating, Deacon oxidation, Fischer-Tropsch, propane dehydrogenation, C4 oxidation, methane coupling, exhaust gas catalysis, bio-based Nylon, fuel cells and vitamins. The topics presented in this eBook have been contributed by researchers from academia as well as industry, making this eBook a well-balanced reference, which could be of particular interest to professional, industrial or service R&D labs.

The use of organoselenium reagents as catalysts is a common thread that runs through the chapters of this book, introducing important aspects of the modern organoselenium chemistry: organocatalysis, green chemistry, bioinspiration, antioxidant activity. The eBook covers the most recent developments in the classical synthetic application of organoselenium reagents such as electrophilic, nucleophilic and free radical reagents. The volume also features a discussion on the synthesis and the synthetic applications of some emerging classes of selenium compounds such as hypervalent selenium species and selenoamides, and also addresses some biological aspects such as the antimicrobial activity of organoselenium derivatives and the biochemistry of selenoproteins. A number of eminent scientists from different research groups were involved in the preparation of the 13 chapters of the book, making Organoselenium Chemistry: Between Synthesis and Biochemistry an excellent reference about selenium chemistry for researchers and graduate students in the field of selenium chemistry.

Halogenated pyridines can be used as interesting starting materials in a wide range of organic synthesis methods. Substituted pyridine compounds are used generally as starting materials in the nucleophilic substitution reactions and have unique scaffolds for the construction of other heterocyclic and macrocyclic compounds. They also have important medicinal properties. Due to synthetic difficulties in the synthesis of the highly substituted pyridine derivatives from pyridine itself, perhalopyridines have a special importance in this regard. This book covers the synthetic reactions and applications of perhalopyridines. An introductory chapter introduces the reader to the physical and chemical properties of halopyridines, followed by 3 chapters which focus on pentafluoropyridine, pentachloropyridine and pentabromopyridine, respectively. The focused chapters provide information about synthetic methods and relevant nucleophilic reactions for each of the listed perhalopyridines and their derivatives. The book is a quick reference on perhalopyridines for students of applied chemistry, organic chemistry and chemical engineering.