Sepsis remains the most common admission diagnosis to ICU and
approximately half of these patients develop some form of cardiac dysfunction. Genetic
factors, large vessel and microcirculatory changes, depressant factors, metabolic
changes, autonomic dysregulation and a myriad of cellular regulators have all been
implicated in the myocardial dysfunction. The cardiomyopathy is reversible may
include elements of LV and RV systolic and diastolic dysfunction. Current approaches
to treatment include guideline based septic shock therapy often along with inotropic
support, however a new approach may include heart rate control.
Keywords: Left ventricular ejection fraction, Sepsis, Septic shock, Ventricular
dysfunction
