Calcium is an essential element in living organism and one of the most
important minerals in the development and maintenance of bones and teeth. Calcium
channel blockers (CCBs) are chemical substances which affect the movement of the
calcium ion, Ca2+, through its specific channels. It is well-known as an important
clinical path the usage of calcium channel blockers in order to decrease blood pressure
of patients with hypertension. There were identified three types of calcium channels:
voltage-sensitive, receptor-operated and stretch-operated.
In history, the first concepts of QSAR appeared when Richet, Meyer and Overton studied
the relation between water/lipid solubility and toxicity or narcosis and Fisher underlined the
importance of the steric configuration of a compound in enzymatic processes. Nowadays,
the efforts to improve the class of CCBs are ongoing. The design of new active molecules
with an improved pharmacotoxicological profile than the already discovered compounds of
its class represent a very important aspect in the new drug development.
