Zebrafish (Danio rerio) represents a powerful model system in cancer research. Recent
observations have shown the possibility to exploit zebrafish to investigate tumor angiogenesis, a pivotal
step in cancer progression and target for anti-tumor therapies. Experimental models have been established
in zebrafish adults, juveniles, and embryos, each one with its own advantages and disadvantages. Novel
genetic tools and high resolution in vivo imaging techniques are also becoming available in zebrafish. It is
anticipated that zebrafish will represent an important tool for chemical discovery and gene targeting in
tumor angiogenesis. This review focuses on the recently developed tumor angiogenesis models in
zebrafish, with particular emphasis to tumor engrafting in zebrafish embryos.
