A series of models as consequential steps in evolution in tumorigenesis is representative
indices of the developmental history in establishment of the metastasizing potentiality of
osteosarcoma. One might allow for the integral representations of further pathway generation in the
evolution of the malignant lesion both in terms of the production of the malignant osteoid and also the
proliferation of the malignant osteoblasts in the first instance. Only in recognition of such sequential
series of hierarchal stages in development of the osteosarcoma, as both an evolved and de-evolved
lesion complex, one can further realize the complexity of the consequences of spread of the tumor. It
is to be further recognized the representation of stages in tumorigenesis as essential primary zones of
consequence in that the osteosarcoma both evolves and de-evolves in its own right beyond simple
dimensions of histogenetic principles as applicable to normal related tissues or organs.
In this sense, an integration of compound factors in pathogenesis is constitutive of the metastasizing
potential for spread of a lesion that both microscopically and macroscopically involves the tumor
origin and the consequence of steps in tumorigenesis as components of interaction and amplification
of the malignant process.
Within overlapping systems of consequence, the pathogenesis of the osteosarcoma is constituted by
the determining roles of establishment of a metastasizing potentiality beyond simple dynamics of a
carcinogenic series of agents or agonists in tumorigenesis.
