This chapter provides an overview of wounds, distinguishing between acute
and chronic types. It describes the dynamic process of wound healing, involving
hemostasis, inflammation, proliferation, and maturation. The role of growth factors and
cytokines in the healing process is highlighted, along with the importance of the
extracellular matrix. The text emphasizes that chronic wounds, often associated with
diseases like diabetes, tumors, or ischemia, have a higher likelihood of recurrence and a
prolonged healing period. Additionally, factors such as infections, stress, age, hormonal
issues, and medications can compromise the natural wound healing process. The
current market offerings for wound dressings, such as gauze and films, often fall short
in promoting effective wound healing due to various limitations. In contrast, specific
types of bioceramics and bioactive glasses have shown potential for co-delivering
therapeutic ions, presenting a smart approach to accelerate the wound healing process.
The study emphasizes the need to explore and develop materials with therapeutic
efficacy, moving beyond mere wound coverage to actively promoting healing and
tissue regeneration.
Keywords: Antibacterial efficacy, Angiogenesis, Bioceramics, Bioactive glass, Cell differentiation, Chronic wounds, Cytokines, Extracellular matrix, Electro spun, Gap junction Cx43, Hageman factor XII, Hemostasis, Hydroxyapatite, Keratinocytes, Micronanofibre, Proliferation, Remodelling, Sol-gel, Woundcare dressings, VEGF.
