Bioceramics: Status in Tissue Engineering and Regenerative Medicine (Part 1)

Recent Advances in Bioactive Glasses and Glass Ceramics

Author(s): Syeda Ammara Batool, Memoona Akhtar, Muhammad Rizwan and Muhammad Atiq Ur Rehman *

Pp: 33-57 (25)

DOI: 10.2174/9789815238396124010005

* (Excluding Mailing and Handling)

Abstract

Bone is a self-healing part of the body, which if damaged, repairs itself in the natural course of events. However, this healing process is deficient if the defect is too large or malignant to mend naturally. Bone regeneration is an age-dependent phenomenon where the older generation is at a disadvantage as compared to the younger generation due to the compromised biological performance as a result of aging. Therefore, it is crucial to create novel and effective ways to treat bone-related troubles. Bioactive glasses (BGs) and glass ceramics (GCs) belong to the thirdgeneration bioactive materials. They not only have the potential to survive in the harsh physiological environment but can also renovate the defects present around them. They also come with the advantage of tunable chemical, physical, and biological properties. Designing an implant or scaffold while playing with distinct characteristics of metals, polymers, and ceramics, bestows a large selection pane in front of humankind for customized and patient-specific products. In this chapter, an overview of the recent advances in the BGs and GCs application in coatings and hydrogels for bone tissue engineering (BTE) is presented. BGs and GCs incorporated coatings and hydrogels loaded with metallic ions, growth factors, and biomolecules provide a complete bundle of features essential for bone repair and growth. Although many BGs and CGs-based products have made it into the market, some inherent challenges like high brittleness and low fracture toughness persist to overcome to date.


Keywords: 3D printed, Antibacterial, Bioactivity, Bioceramics, Biomaterials, Biopolymers, Bone, Coatings, Degradation, Electrospinning, Glasses, Hydrogels, Hydroxyapatite, Metallic ions, Osteoconductive, Osteointegration, Regeneration, Resorbable, Scaffolds, Tissue engineering.

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