Anthocyanins, natural pigments abundantly present in fruits
and vegetables, have demonstrated diverse bioactive properties, including antioxidant
and anti-inflammatory effects. There is growing interest in exploring their potential
role in cancer prevention and treatment due to these properties.
Objective:This study aimed to comprehensively investigate the impact of anthocyanins
on cancer, elucidating the underlying mechanisms through In vitro and In vivo
experiments.
Method:The study was conducted to identify studies investigating the effects of
anthocyanins on cancer cells. The selected studies encompassed In vitro experiments
utilizing cell cultures and In vivo investigations employing animal models to assess the
potential inhibitory effects of anthocyanins on tumor growth. The review focused on
molecular and cellular assays from these studies, specifically exploring the modulation
of oxidative stress, inflammation, apoptosis, angiogenesis, and cell cycle regulation by
anthocyanins. The methodological approaches and key findings from these studies
were critically analyzed to provide a comprehensive overview of the current state of
knowledge regarding the role of anthocyanins in cancer.
Result: The findings revealed that anthocyanins exerted potent antioxidant effects,
mitigating oxidative stress and DNA damage in cancer cells. Anti-inflammatory
properties were demonstrated by the suppression of key inflammatory pathways.
Anthocyanins induced apoptosis in cancer cells, leading to programmed cell death
while sparing normal cells. Furthermore, they exhibited antiangiogenic effects by
disrupting the formation of blood vessels essential for tumor growth. The modulation
of cell cycle progression was also observed, suggesting a role in preventing
uncontrolled cell proliferation.
Keywords: Anthocyanins, Antioxidants, Anti-inflammatory, Apoptosis, Angiogenesis, Cell cycle regulation, Cancer.
