Neurodegenerative diseases are a heterogeneous group of disorders and are
the leading cause of morbidity and disability. These are described by the progressive
degeneration of the neurons and impaired function of the central nervous system.
Prevailing neurodegenerative diseases in the world include Alzheimer's disease and
Parkinson's disease and reports predict that on average, the prevalence of both diseases
will double in a span of the next twenty years. Pieces of evidence showed that the
immune system is profoundly involved in brain development, maintenance, and repair
as well as in damage, therefore, may provide a wide scope to focus on the
neuroinflammation-based therapeutic approaches. In this chapter, the various
neuroinflammatory responses will be discussed during the onset and progression of
both Alzheimer’s and Parkinson’s disease pathologies. We will be focusing on both
central and peripheral inflammatory responses and their consideration for disease
diagnosis and therapeutics.
Keywords: Alzheimer’s disease, Disorders, Neuroinflammation, Parkinson’s, Pathologies.
