Heterocyclic compounds are one of the most significant sources of bioactive molecules. Pyrimidines and pyrimidinones are a class of nitrogen-containing
heterocyclic compounds with significant biological activities. Among the different
applications of these compounds in medicinal chemistry, their anti-inflammatory
activities have attracted the attention of the scientific community to explore their
chemistry. Some of these derivatives have been found to inhibit the production of proinflammatory cytokines and chemokine enzymes, which are involved in the recruitment
and activation of immune cells at sites of inflammation. The chapter outlines the range
of methods available to create different pyrimidine and pyrimidinone derivatives along
with their anti-inflammatory activities.
Keywords: Anti-inflammatory agents, Biginelli reaction, Biological activity, Dihydropyrimidinones, Drug discovery, Heterocyclic compounds, Inflammation, Medicinal chemistry, Pharmaceuticals, Pyrimidines and pyrimidinones.
