The human body is colonized by microbial cells that are estimated to be as
abundant as human cells, yet their genome is roughly 100 times the human genome,
providing significantly more genetic diversity. The past decade has observed an
explosion of interest in examining the existence of microbiota in the human body and
understanding its role in various diseases, including prostate cancer. Studies show that
probiotics provide positive results in prostate cancer prevention and treatment.
However, some studies argue that they should not be used, putting forward the fact
they may cause infection in patients with very weak immunity. This chapter
summarizes key microbiota alterations observed in prostate cancer niches, their
association with clinical stages, and their potential use in anticancer therapy and
management. In addition, the chapter discusses microbiota-based therapeutic
approaches for prostate cancer.
Keywords: Androgen, Cancer, Gut, Hormone, Immunology, Inflammation, Intervention, Metabolism, Microenvironment, Microbiota, Modulation, Prostate Cancer, PSA, PCa, Probiotic, Risk factors, Therapy.
