Nature is replete with an arsenal of compounds that can be investigated for
their therapeutic potential. The immune system involvement in severe chronic illnesses
or emerging infectious diseases has provided clinical evidence. The prevention and
treatment of these diseases targeted at the immune system with natural
immunomodulators are gaining momentum, owing to their diverse array of activities.
Treating acute illnesses with modern medicines has been successful; however, treating
chronic illness treatment remains elusive and disappointing. Notably, this chapter
reviews the natural resources of immunomodulators. Natural immunomodulators from
plants, marine, and animals are of prime importance, and they possess many
pharmacological activities. Similarly, microbiota modifiers - prebiotics, probiotics, and
micronutrients- are imperative in restoring immune homeostasis. This chapter
summarizes these natural immunomodulators and their power to boost immunity and
human well-being.
Keywords: Alkaloids, Glycosides, Micronutrients, Microbiota, Natural Immunomodulators, Prebiotics, Probiotics
