Dengue is one of the most important arboviral diseases recorded in the
world. Dengue, a public health problem in tropical and subtropical countries, is spread
by female Aedes mosquito bites. Among Aedes mosquitoes, Aedesaegypti is the
primary vector and Aedesalbopictus is the less infective secondary vector [1]. Dengue
hemorrhagic fever (DHF) is a severe form of the disease, that causes differential
expression of the TLRs in dendritic cells (DCs). TLR3 and TLR9 in DCs of patients
with early onset of dengue fever were unregulated, whereas in severe cases, poor
expression of TLR3 and TLR9 is observed [2]. This kind of alteration in the TLR
expression during dengue may alter the clinical manifestation of the disease. However,
this can be considered for further research on therapeutics.
Keywords: Human peripheral blood mononuclear cells (PBMC), NF-kB mediated pathways.
