It has been well-established that mitochondria play a crucial role in aging.
Thus, targeting mitochondria is a leading approach for anti-aging pharmacological
interventions. On the other hand, the anti-aging effect of taurine (TAU) is an exciting
feature of this amino acid. Effects of TAU on mitochondria-facilitated oxidative stress
as well as mitochondria-mediated cell death, seem to play a pivotal role in its antiaging
properties. The current chapter will discuss a good body of investigations that have
converged at a consensus regarding mitochondria (dynamics and functionality) and
oxidative stress as essential mechanisms involved in the aging process. In each part, the
potential antiaging properties of TAU and its mechanisms of action are also
highlighted. Finally, in the last section of this chapter, we described the possible role of
recently-discovered signaling pathways (i.e., aryl hydrocarbon receptors; AhR) on
mitochondria and their relevance to senescence.
Keywords: Cell death, Endoplasmic reticulum stress, Oxidative stress, Reproduction, Senescence.
