Neurodegenerative disorders are the conditions in which neurons of the
central and peripheral nervous systems degenerate. Various cellular and molecular
processes are associated with the progression of such degeneration, including
inflammation, apoptosis, and axonal degeneration. Recently, SIRTUINs have emerged
as one of the key factors associated with neurodegenerative disorders. SIRTUINs are
involved in the regulation of several cellular and molecular processes in neurons of the
nervous system through the deacetylation of target proteins. The chapter focuses on the
modulatory role of SIRTUINs in neurodegenerative disorders and their potential
therapeutic application.
Keywords: Acetylation, Brain disorders, Histone modifications, Neurodegeneration, SIRTUINs.
