The oral route is an extremely accepted route for the administration of
several drug delivery systems. This route exhibits several merits for the controlled and
sustained release of different formulation types to attain enhanced therapeutic
responses. Gastro-retentive nanocarriers (NCs) (GRNCs) have advantages due to their
aptitude for extended retaining potential in the stomach environment and thereby
elevate gastric retention and augmenting bioavailability of the drug molecules. This
chapter covers various merits and demerits of gastro-retentive NCs. Further, it also
discusses some gastro-retentive strategies and their applications in the therapy of
various illnesses, for instance, swelling NCs, porous NCs, floating/non-floating NCs,
lipid NCs, Polymeric NCs, bioadhesive NCs, and magnetic NCs, etc.
Keywords: Bioavailability, Controlled drug release, Drug delivery, Eudragit L100, Floating systems, Gastric cancer, Gastro-retentive carriers, Gastric retention time, Gastric emptying time, Gastrointestinal, HPMC, Ion-exchange resin, Lipids nanocarriers, Mucoadhesive nanocarriers, Magnetic nanocarriers, Polymer, Polymeric nanocarriers, Stomach, Sustained drug release, Super porous systems.
