Flavonoids belong to a class of natural, polyphenolic dietary compounds
which modify the neuropathological state of the brain. Some flavonoids like quercetin
and other, reduce the inflammation, carcinogenicity, and oxidation promotes
neuroprotection and comprises the major component of cosmetics, medicinal and
dietary supplements. Daily intake of flavonoids helps to mitigate the risk of several
neurological disorders like Alzheimer’s disease, Parkinson’s disease, multiple sclerosis,
etc. Flavonoids exhibit their pharmacological effect through various mechanisms like
cholinesterase inhibition, scavenging free radicals, memory enhancement via
attenuation of amyloid plaques, tau targeting detoxification and neural
antiinflammation. Administration of flavonoids to biological system has to pass
through several biological checkpoints like first pass metabolism, intestinal absorption,
and entry into blood brain barrier. Flavonoids exhibit difference in pharmacokinetic
and pharmacodyanmic profile due to difference in their structures. Recent literature
reports have proved promising therapeutic potential in neurological disorders. This
chapter highlights the recent development of flavonoids prevailing in the field of
neurodegenerative, its limitations and drug delivery approaches to encounter the
challenges.
Keywords: Flavonoids, Alzheimer’s, Parkinson's, Natural Biological, Neurodegenerative disorder.
