Despite clinical and pharmacological advancement in medical science breast
cancer has become a global concern due to the high mortality rate. Breast cancer is
mainly associated with altered redox status, cell cycle, chronic inflammation, and
increased proliferative rate. Breast cancer has various molecular subtypes and adequate
knowledge of these altered cell cycle regulatory cascades and molecular subtypes of
breast cancer is a must for proper prognosis and its successful treatment. The discovery
of drugs with anticancer properties, particularly against the specific subtype of breast
cancer has become a challenging task for cancer researchers. Dietary polyphenolic
compounds as cancer chemopreventive agents have drawn much attention among
researchers because polyphenolic compounds are natural in origin with lesser side
effects and have a wide range of action against various subtypes of breast cancer.
Dietary compounds with antioxidant properties have been reported to act on an array of
genes and proteins associated with breast cancer pathogenesis and thus regulate the
signaling cascade related to autophagy, chronic inflammation, apoptosis, and cell cycle
regulation. All in all, these natural compounds regulate growth and progression of a
tumour with less or no side effects. Thus, the current article focuses primarily here on
various aspects of breast cancer and food polyphenolic compounds as wellas their
molecular mechanism for managing breast cancer.
Keywords: Epigallocatechin gallate, Polyphenols compounds, Quercetin, Resveratrol, ROS.
