Recurrent Aphthous Stomatitis (RAS), which has symptoms like pain while
eating, speaking, or swallowing, is one of the most hurtful oral mucosal inflammatory
ulcerative diseases [1]. Tumor necrosis factor α (TNF α), has a main role in
predominantly cell-mediated immune response due to the pathogenesis of RAS. The
aim of this study was to investigate the therapeutic effects of Beta-glucan on the
response of lymphocytes with and without phytohemagglutinin (PHA), a T lymphocyte
mitogen, in treatment of RAS. RAS, estimated by the Ulcer Severity Score (USS),
shows ulcer characteristics (number, size, duration, ulcer-free period, site, and pain).
Keywords: Beta Glucan, Diabetic Ulcers, Recurrent Aphthous Stomatitis.
