Therapeutic cancer drugs have been developedfor specific cancer cell targets
with no sideeffects and can remain stable until eliminating the cancer cells.
Differentcompositions and alteredexpressions of lipids and proteins on cell membrane
between normal and cancer cells have been an interesting development for targeted
cancer cell therapy. A good choice of various anticancer drugs is anticancer peptides
which are easy to synthesize and modify, stable in blood circulation and specific to the
cancer cells. The molecular mechanism of the anticancer peptides for cancer
eradication begins with the delivery of the specific anticancer peptides to the cancer
cells. Then, the interaction of the cell membrane and the anticancer peptides via
receptors or charge interaction leads to membrane disruption via pore formation and
then apoptosis. Moreover, the anticancer peptides could be modified to improve cell
permeability, stability in blood circulation without degradation or digestion, and cancer
specificity. Currently, many anticancer peptides are ongoing in clinical trials to
examine the efficacy with no side effects for clinical use in future therapy.
Keywords: Anticancer Peptide, Cancer, Clinical Trial, Membrane, Targeted
Therapy.
