Cancer is the most dreadful disease and has significant health problems
occurring worldwide. Cancer can arise from abnormal proliferation in a cell, and there
are a diverse number of signaling pathways that regulate cell proliferation and its
behavior. The signaling pathways contribute to the development and cellular
homeostasis in cells. In diseases, especially cancer, developmental components of these
pathways often become mutated or in many cases, overexpressed, which cause
interruption or deregulation of cellular signaling. Cancer treatment action can target
multiple signaling pathways and their molecular targets. This chapter provides an
overview of the key pathways involved in tumor development and progression and
components of the signaling pathways and their cross-talk associated with therapeutic
implications.
Keywords: Cancer, Death Receptor, Drug Targets, Insulin-like Growth Factor
Receptor, Epidermal Growth Factor Receptor, Fibroblast Growth Factor Receptor,
G –Protein Coupled Receptor, Membrane Receptors, Platelet-derived Growth
Factor, Receptor Tyrosine Kinase, Signaling Pathways, Targeted Therapy,
Therapeutic Strategies.
