Over the past decades, the survival rate of head and neck cancers has not
significantly changed. Recently, the importance of the inflammatory responses in head
and neck cancer has been a hot topic and of increasing interest. There has been
suspicion about the relationship between inflammation and carcinogenesis, and thus,
many works had proven these relations. Manipulation of the inflammatory mediators
has been experimented with, to reduce the tumor burden, treat as well as prevent the
cancer occurrence or second primary. This chapter summarizes the relationship
between inflammation and cancer, emphasizing epidemiological and clinical evidence
and proposing the current potential targets of anti-inflammatory agents for the
therapeutic approach of head and neck cancer (HNC). We hope this knowledge will
help us combat carcinogenesis and reduce the morbidity of the current conventional
treatment for a better quality of life.
Keywords: Head and neck cancer, Inflammation, Treatment.
