In some countries, Malaria is still a challenge. The highest rates of mortality
are reported in sub-Saharan Africa, where children under five years of age, pregnant
women and immunocompromised patients are the most vulnerable groups. People
living in these endemic areas still do not receive proper antimalarial therapy.
Insecticides resistance, antimalarial drug resistance and commercialization of
counterfeit and substandard antimalarials, are key factors contributing to complexity in
malaria control; trying to find new alternatives to treat and control malaria, some
members of the scientific community, have recently started to work in the field of stem
cell therapy in experimental malaria models. The purpose of the present chapter is to
make a general review concerning various aspects of the use of stem cell therapy and
how these findings could improve clinical aspects during malaria pathogenesis and
could be used in the field of antimalarial drug design. An overview of the effect of the
parasite on the stem cells production in the host, as in hematopoiesis and in
neurogenesis, is also described.
Keywords: Adult Neurogenesis, Bone Marrow Stromal Cells, Cognitive
Dysfunction, Hepatocytes, Hematopoiesis, Hippocampus, Malaria, Malaria
Pathogenesis, Malaria Drug Design, Mesenchymal Cells, Memory, Murine
Malaria, Neurogenesis, Plasmodium falciparum, Plasmodium vivax, Stem Cell
Therapy.
