Hypothalamic obesity is a condition with extremely high morbidity.
Mechanisms leading to the profoundly disturbed energy homeostasis are complex.
Craniopharyngioma is one of the most common pathogenesis of hypothalamic obesity,
which leads to the damage of hypothalamic nucleis due to the tumor compression
or/and cytokines stimulation. The purpose of the present chapter is to summarize data
on the prevalence of hypothalamic obesity, discuss the clinical features and review the
diagnosis and treatment of these patients. Differences tumor growth patterns and
locations should be considered when comparing outcomes and survival across different
treatment paradigms in patients with CP. Further studies should be conducted to better
understand the mechanisms of rapid weight gain and metabolic syndrome in patients
with CP and could be used to enhance effective treatments and establish prevention
strategy.
Keywords: Circadian rhythm, Craniopharyngioma, Obesity.
