This chapter discusses alternative methods for drug delivery. Specifically,
we focused on the use of mesenchymal stem cells (MSCs) and to show how these stem
cells can be available as off-the-shelf cells. The advantages of MSCs are their unique
immune properties and the ability of these cells to migrate to areas of inflammation
such as tumors. In addition, MSCs are easy to harvest with several fold expansion, as
well as little to no ethical concern. Although MSCs are similar by phenotype, the
effectiveness from each source needs to be compared for homing to the desired
organ/tissue, intercellular communication and the delivery of non-coding RNA through
secreted exosomes. A major advantage of MSCs is the ease by which they can become
available as off-the-shelf cells containing the drugs or RNA for immediate transplant to
patients. There is little concern that MSCs will linger for a prolonged period because
the clinical and experimental evidence indicate that allogeneic MSCs (off-the-shelf)
can be readily cleared by the immune system. The chapter discusses why there is an
immediate need for cellular delivery of drugs, given the cumbersome regulation and
confounds of current single drug trials.
Keywords: Breast cancer, Cancer stem cell, Connexin, Cytokines, Drug delivery,
Exosomes, Mesenchymal stem cells, miRNA, Non-coding RNA.
